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Resting B cells expand a CD4+CD25+Foxp3+ Treg population via TGF-beta3. | LitMetric

Resting B cells expand a CD4+CD25+Foxp3+ Treg population via TGF-beta3.

Eur J Immunol

Department of Microbiology and Immunology, Loyola University Chicago, Maywood, IL 60153, USA.

Published: September 2008

AI Article Synopsis

Article Abstract

Regulatory T cells (Treg) play critical roles in maintaining tolerance and preventing autoimmunity. It is not fully clear how these cells are generated and maintained. Here, we show that resting B cells are able to expand Treg. This expansion requires TGF-beta3 and signaling through the TCR and CD28. Upon activation, B cells express less TGF-beta3, which reduces their capacity to expand Treg and which also results in increased Treg death. This may ensure that B cells can function as potent professional antigen presenting cells during infections. However, in the absence of any infection, we find that B-cell-deficient microMT mice have decreased percentages of Treg in the periphery. Our data suggest that resting B cells, which may be presenting self-antigens to T cells, can expand and maintain specific Treg and thus might be involved in the prevention of autoimmunity.

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Source
http://dx.doi.org/10.1002/eji.200838201DOI Listing

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