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Harmonized Data Quality Indicators Maintain Data Quality in Long-Term Safety Studies Using Multiple Sclerosis Registries/Data Sources: Experience from the CLARION Study.
Clin Epidemiol
October 2024
Merck Healthcare KGaA, Darmstadt, Germany.
Purpose: Understanding the long-term safety of disease-modifying therapies for multiple sclerosis (MS) in routine clinical practice can be undertaken through registry-based studies. However, variability of data quality across such sources poses the challenge of data fit for regulatory decision-making. CLARION, a non-interventional cohort safety study of cladribine tablets, combines aggregated data from MS registries/data sources, except in Germany (which utilizes primary data collection).
View Article and Find Full Text PDFPushing the boundaries of rare disease diagnostics with the help of the first Undiagnosed Hackathon.
Nat Genet
November 2024
Department of Clinical Genetics and Genomics, Karolinska University Hospital, Stockholm, Sweden.
Facing the climate change: Is radiotherapy as green as we would like? A systematic review.
Crit Rev Oncol Hematol
December 2024
Division of Radiation Oncology, European Institute of Oncology IRCCS, Milan, Italy; Department of Oncology and Hemato-oncology, University of Milan, Milan, Italy.
Purpose: To focus on the ecological footprint of radiotherapy (RT), on opportunities for sustainable practices, on future research directions.
Methods: Different databases were interrogated using the following terms: Carbon Footprint, Sustainab*, Carbon Dioxide, Radiotherapy, and relative synonyms.
Results: 931 records were retrieved; 15 reports were included in the review.
Assigning the unassigned: A signature-based classification of rDNA metabarcodes reveals new deep-sea diversity.
PLoS One
March 2024
Institute of Oceanology, Polish Academy of Sciences, Sopot, Poland.
Environmental DNA metabarcoding reveals a vast genetic diversity of marine eukaryotes. Yet, most of the metabarcoding data remain unassigned due to the paucity of reference databases. This is particularly true for the deep-sea meiofauna and eukaryotic microbiota, whose hidden diversity is largely unexplored.
View Article and Find Full Text PDFA novel swine model of selective middle meningeal artery catheterization and embolization.
J Neurointerv Surg
February 2024
Neurosurgery and Radiology and Canon Stroke and Vascular Research Center, University at Buffalo Jacobs School of Medicine and Biomedical Sciences, Buffalo, New York, USA
Background: Middle meningeal artery (MMA) embolization is a promising intervention as a stand-alone or adjunct treatment to surgery in patients with chronic subdural hematomas. There are currently no large animal models for selective access and embolization of the MMA for preclinical evaluation of this endovascular modality. Our objective was to introduce a novel in vivo model of selective MMA embolization in swine.
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