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Dynamics of Plasmodium falciparum alleles in children with normal haemoglobin and with sickle cell trait in western Uganda. | LitMetric

AI Article Synopsis

  • - The study examines Plasmodium falciparum populations in western Uganda, focusing on the genetic diversity of the malaria parasite found in symptomatic and asymptomatic carriers, particularly highlighting the role of sickle cell trait (HbAS) carriers.
  • - Researchers analyzed blood samples from various locations, revealing significant genetic diversity with multiple alleles detected in both symptomatic children and asymptomatic carriers, particularly noting higher multiplicity of infection (MOI) in one location compared to another.
  • - The findings suggest that asymptomatic children with sickle cell trait (HbAS) have a higher variety of malaria strains and may act as a reservoir for different parasite genotypes, contributing to the overall genetic diversity of P. falciparum in low-trans

Article Abstract

We describe the diversity of Plasmodium falciparum populations in western Uganda and assess the role that asymptomatic malaria carriers with sickle cell trait (HbAS) may be playing on the Plasmodium population structure. We genotyped P. falciparum in 291 samples using merozoite surface protein (MSP) 1 and 2 loci. Extensive genetic diversity was detected among symptomatic children in Mbarara (20 MSP1 alleles; 31 MSP2 alleles) and Kagando, Kasese (19 MSP1 alleles; 30 MSP2 alleles). Multiplicity of infection (MOI) was significantly higher in Kagando, Kasese than in Mbarara, with 2.7 and 2.1 genotypes/PCR positive sample with MSP2 marker, respectively. Similar strains were circulating in the two sites; however, a few strains specific to individual sites were observed. Prevalence of HbAS was 36% (12/33) among asymptomatic children in Kisinga sub-county, Kasese. In asymptomatic children, MOI was age-dependent and higher in HbAS carriers than HbAA, suggesting that HbAS carriers harbour a wider range of P. falciparum genotypes. Sickle cell trait may influence rapid acquisition of premunition by creating a reservoir of variant parasite strains in the host. The high level of genetic diversity demonstrated here shows that even in areas with low or seasonal transmission, high levels of parasite polymorphism can occur.

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Source
http://dx.doi.org/10.1016/j.trstmh.2008.07.023DOI Listing

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