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Exploring the Therapeutic Potential of Orel & Luu Leaf Extracts for Memory Loss in Alzheimer's Disease: Novel Findings and Functional Food Applications.
ACS Omega
July 2024
Research Center of Ginseng and Medicinal Materials, National Institute of Medicinal Materials, Ho Chi Minh City 700000, Vietnam.
Article Synopsis
- Recent research on Orel and Luu leaf extracts shows promise for Alzheimer's treatment, revealing valuable chemical compositions and bioactivities.
- Various beneficial phytochemicals were identified, such as polyphenols and flavonoids, with HPLC-MS uncovering 23 significant compounds, including epicatechin gallate and quercetin.
- The ethanol extract demonstrated strong antioxidant and acetylcholinesterase (AChE) inhibition, improving memory and longevity in mice, suggesting potential applications in memory impairment therapies.
Characterizing the potentially neuronal acetylcholinesterase reactivity toward chiral pyraclofos: Enantioselective insights from spectroscopy, in silico docking, molecular dynamics simulation and per-residue energy decomposition studies.
J Mol Graph Model
January 2022
School of Water and Environment, Chang'an University, Xi'an, 710054, China; Key Laboratory of Subsurface Hydrology and Ecological Effect in Arid Region of Ministry of Education, Chang'an University, Xi'an, 710054, China; Department of Agricultural Chemistry, Qingdao Agricultural University, Qingdao, 266109, China. Electronic address:
Chiral organophosphorus agents are distributed ubiquitously in the environment, but the neuroactivity of these asymmetric chemicals to humans remains uncertain. This scenario was to explore the stereoselective neurobiological response of human acetylcholinesterase (AChE) to chiral pyraclofos at the enantiomeric scale, and then decipher the microscopic basis of enantioselective neurotoxicity of pyraclofos enantiomers. The results indicated that (R)-/(S)-pyraclofos can form the bioconjugates with AChE with a stoichiometric ratio of 1:1, but the neuronal affinity of (R)-pyraclofos (K = 6.
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