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Developing and validating a comprehensive polygenic risk score to enhance keratoconus risk prediction.
Hum Mol Genet
November 2024
QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Queensland 4006, Australia.
Article Synopsis
- This study aimed to create and validate a polygenic risk score (PRS) for keratoconus to improve how well we can identify people at higher risk for the condition, which can lead to serious vision problems after procedures like LASIK.
- Researchers used multi-trait analysis and data from large biobanks to build and assess the PRS models' accuracy in predicting keratoconus risk.
- The results showed that the new PRS models significantly improved the prediction of keratoconus risk, suggesting they could be useful in clinical settings to identify individuals at risk and potentially prevent complications after LASIK surgery.
Impact of Scleral Lenses on Visual Acuity and Ocular Aberrations in Corneal Ectasia: A Comprehensive Review.
J Pers Med
October 2024
Ophthalmology, Campus Bio-Medico University, 00128 Rome, Italy.
Corneal ectasias, including keratoconus (KC), pellucid marginal degeneration (PMD), and post-LASIK ectasia, poses significant visual rehabilitation challenges due to the resultant irregular astigmatism, myopia, and higher-order aberrations (HOAs). These conditions often resist traditional corrective methods, necessitating advanced optical solutions. Scleral lenses (SLs) have emerged as a primary non-surgical option for managing these complex corneal irregularities.
View Article and Find Full Text PDFLong-term results of allogenic corneal lenticule of hyperopic SMILE for post-LASIK ectasia.
iScience
September 2024
Eye Institute and Department of Ophthalmology, Eye & ENT Hospital, Fudan University, Shanghai, China.
Post-laser-assisted keratomileusis (LASIK) corneal ectasia is a severe complication of corneal refractive surgery, and cryopreserved lenticules from hyperopic small incision lenticule extraction (SMILE) may offer a promising treatment though their long-term safety and efficacy are still under investigation. In this prospective case series, six eyes from six patients with post-LASIK ectasia received lenticules (mean cryopreserved time: 63 days). The procedure involved lifting the corneal flap, implanting the lenticule, and repositioning the flap.
View Article and Find Full Text PDFArticle Synopsis
- Large language models like ChatGPT-3.5 have potential for aiding self-directed medical learning, but their accuracy in specialized topics is under scrutiny.
- A study with 23 medical students compared ChatGPT-3.5 to traditional internet searches regarding the Randleman criteria, revealing ChatGPT-3.5 was only accurate for 26.1% of responses, whereas internet searches were 100% accurate.
- The findings suggest that ChatGPT-3.5 can mislead users, and students should critically evaluate its outputs while future efforts focus on improving AI accuracy and prompt effectiveness.
Posterior corneal surface stability after femtosecond laser-assisted in situ keratomileusis in patients with myopia and myopic astigmatism.
Indian J Ophthalmol
August 2024
Universiti Malaya Eye Research Centre, Department of Ophthalmology, Faculty of Medicine, Universiti Malaya, Kuala Lumpur, Malaysia.
Purpose: To evaluate the variation and stability of the posterior cornea surface parameters (posterior cornea curvature [PCC], posterior cornea astigmatism [PCA], and posterior cornea elevation [PCE]) after femtosecond laser-assisted in situ keratomileusis (LASIK) in patients with myopia and myopic astigmatism over a period of 6 months or longer.
Methods: This retrospective study comprised 284 right eyes. Patients aged 18 years or older with myopia up to -12.
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