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| http://dx.doi.org/10.1073/pnas.0807334105 | DOI Listing |
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Rolling down the pilus formation of gram-positive bacteria: underlining the importance of Sortase C as a drug target.
Biofouling
January 2025
Amity Institute of Biotechnology, Amity University Rajasthan, Jaipur, India.
Bacteria possess hair-like projections on their surface termed pili. The primary function of a pilus is to enable bacterial cell attachment to the host. Since pili are associated with cell adhesion, they play a major role in bacterial colonization and infection.
View Article and Find Full Text PDFBiogenesis and Functionality of Sortase-Assembled Pili in Gram-Positive Bacteria.
Annu Rev Microbiol
November 2024
Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, California, USA.
Article Synopsis
- Pili, or fimbriae, are unique proteins made of linked subunits that are found on the surface of gram-positive bacteria, assembled by an enzyme called sortase.
- These proteins are important for a variety of functions, including adhesion to surfaces, immune system interaction, and roles in disease-causing abilities of bacteria.
- The review discusses ongoing research into how pili are formed, their functions, potential applications in vaccines, and the future of this area of study.
The HtrA chaperone monitors sortase-assembled pilus biogenesis in Enterococcus faecalis.
PLoS Genet
August 2024
Department of Microbiology and Molecular Medicine, University of Geneva, Geneva, Switzerland.
Sortase-assembled pili contribute to virulence in many Gram-positive bacteria. In Enterococcus faecalis, the endocarditis and biofilm-associated pilus (Ebp) is polymerized on the membrane by sortase C (SrtC) and attached to the cell wall by sortase A (SrtA). In the absence of SrtA, polymerized pili remain anchored to the membrane (i.
View Article and Find Full Text PDFMolecular basis for sortase-catalyzed pilus tip assembly.
mBio
September 2024
Division of Oral & Systemic Health Sciences, School of Dentistry, University of California, Los Angeles, California, USA.
Unlabelled: During pilus assembly within the Gram-positive bacterial envelope, membrane-bound sortase enzymes sequentially crosslink specific pilus protein monomers through their cell wall sorting signals (CWSS), starting with a designated tip pilin, followed by the shaft made of another pilin, ultimately anchoring the fiber base pilin to the cell wall. To date, the molecular determinants that govern pilus tip assembly and the underlying mechanism remain unknown. Here, we addressed this in the model organism .
View Article and Find Full Text PDFStructural and functional insights of sortases and their interactions with antivirulence compounds.
Curr Res Struct Biol
June 2024
Research Center for Excellence in Microscopy, Department of Biotechnology, Kumaraguru College of Technology, Coimbatore, 641049, Tamil Nadu, India.
Sortase proteins play a crucial role as integral membrane proteins in anchoring bacterial surface proteins by recognizing them through a Cell-Wall Sorting (CWS) motif and cleaving them at specific sites before initiating pilus assembly. Both sortases and their substrate proteins are major virulence factors in numerous Gram-positive pathogens, making them attractive targets for antimicrobial intervention. Recognizing the significance of virulence proteins, a comprehensive exploration of their structural and functional characteristics is essential to enhance our understanding of pilus assembly in diverse Gram-positive bacteria.
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