Acute intermittent porphyria presenting with a subarachnoid haemorrhage.

Ann Clin Biochem

Clinical Laboratories, University Hospital Aintree, Liverpool L9 7AL, UK.

Published: November 2008

A 47-year-old man presented with abdominal pain, neck stiffness, severe transient hypertension and unusually dark urine. Cerebrospinal fluid investigations and angiography confirmed the diagnosis of a subarachnoid haemorrhage. Porphyrin studies on the patient and his family demonstrated that the family has acute intermittent porphyria. This is the second case report of an acute hepatic porphyria presenting with a subarachnoid haemorrhage. Acute transient hypertension during the attack of porphyria caused the rupture of an intracranial arterial aneurysm.

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http://dx.doi.org/10.1258/acb.2008.008084DOI Listing

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