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Striatal 19S Rpt6 deficit is related to alpha-synuclein accumulation in MPTP-treated mice. | LitMetric

Striatal 19S Rpt6 deficit is related to alpha-synuclein accumulation in MPTP-treated mice.

Biochem Biophys Res Commun

Department of Pharmacology, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, 1# Xiannongtan Street, Xuanwu District, Beijing 100050, China.

Published: November 2008

AI Article Synopsis

Article Abstract

Striatal mitochondrial proteins were investigated using proteomics in the 1-methyl 4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model of Parkinson's disease. Four proteins, 19S proteasome ATPase Rpt6 (19S Rpt6), Lectin-related nature killer cell receptor LY 49S, Zinc finger A20 domain containing 1, and the sodium channel-associated protein 1 isoform 2, were significantly decreased while alpha-synuclein was increased in MPTP-treated mice. The altered levels of 19S Rpt6 and alpha-synuclein were further verified by Western blot. Experiments using small interfering RNA (siRNA) showed that alpha-synuclein was increased by 50% in cultured striatal neurons when 19S Rpt6 was knocked down. Taken together, our results imply that a deficiency in 19S Rpt6 may be partially related to the MPTP-induced increase in alpha-synuclein in the striatum.

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Source
http://dx.doi.org/10.1016/j.bbrc.2008.08.142DOI Listing

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