Objective: To study the effects of ginsenoside Rg1 on the expression of insulin-like growth factor-1 (IGF-1) in the brain of rats after the experimental brain contusion.
Methods: A total of twenty-six Wistar rats were randomly divided into normal control group (n=2), untreated group (n=8) and ginsenoside Rg1 group (n=16). Brain injuries were induced in rats by a mechanical striking device. The brain tissues were extracted at different times after brain injury (6th hour, 12th hour, 2nd day, 6th day), then the expression of IGF-1 in brain tissue was examined by immunohistochemical method.
Results: In comparison with the normal control group, the expression of IGF-1 in the brain tissues was increased in the untreated group after the brain contusion (P<0.05). The expression of IGF-1 in brain tissues in ginsenoside Rg1 group was significantly increased as compared with the untreated group (P<0.05).
Conclusion: Ginsenoside Rg1 enhances the recovery of the contused brain through increasing the expression of IGF-1.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.3736/jcim20080907 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
A Novel Ginsenoside-Transforming α-L-Rhamnosidase from : Screening, Characterization and Application.
Biomolecules
December 2024
Department of Biotechnology, Hankyong National University, Anseong 17579, Republic of Korea.
Despite the rapid advancement of glycosidase biotechnology, ginsenoside-transforming rhamnosidases remain underexplored due to a lack of research. In this study, we aimed to bridge this gap by evaluating eight putative rhamnosidases for their ability to transform ginsenosides. Among them, a novel rhamnosidase (C118) from was identified as being efficient at hydrolyzing ginsenoside Re.
View Article and Find Full Text PDFGinsenoside Rg1 Alleviates Blood-Milk Barrier Disruption in Subclinical Bovine Mastitis by Regulating Oxidative Stress-Induced Excessive Autophagy.
Antioxidants (Basel)
November 2024
Animal Science and Technology College, Beijing University of Agriculture, Beijing 100096, China.
As a critical disease usually infected by , with a worldwide effect on dairy animals, subclinical mastitis is characterized by persistence and treatment resistance. During mastitis, the blood-milk barrier (BMB)'s integrity is impaired, resulting in pathogen invasion and milk quality decline. In this study, it was found that ginsenoside Rg1 (Rg1), a natural anti-inflammatory and antioxidant compound derived from ginseng, inhibited the onset of tight junction (TJ) dysfunction and ameliorated lipoteichoic acid (LTA)-induced BMB disruption inside and outside the organisms.
View Article and Find Full Text PDFGinsenoside Rg1: A bioactive therapeutic agent for diverse liver diseases.
Pharmacol Res
January 2025
Shanghai Key Lab of Human Performance (Shanghai University of sport), Shanghai University of Sport, Shanghai 200438, China; The Key Lab of Exercise and Health Sciences of Ministry of Education, Shanghai University of Sport, Shanghai 200438, China. Electronic address:
Diverse liver diseases are characterised by late diagnosis and rapid progression and have become one of the major threats to human health. To delay the transition from benign tissue lesions to a substantial organ injury, scientists have gradually applied natural compounds derived from plants as a complementary therapy in the field of hepatology. Ginseng (Panax ginseng C.
View Article and Find Full Text PDFRg1 improves Alzheimer's disease by regulating mitochondrial dynamics mediated by the AMPK/Drp1 signaling pathway.
J Ethnopharmacol
December 2024
Hubei University of Chinese Medicine, Basic Medical College, Wuhan, Hubei, 430070, China; Engineering Research Center of TCM Protection Technology and New Product Development for the Elderly Brain Health, Ministry of Education, Wuhan, Hubei, 430070, China; Hubei Shizhen Laboratory, Wuhan, Hubei, 430070, China. Electronic address:
Ethnopharmacological Relevance: Alzheimer's disease (AD) is the most prevalent form of dementia, characterized by a complex pathogenesis that includes Aβ deposition, abnormal phosphorylation of tau protein, chronic neuroinflammation, and mitochondrial dysfunction. In traditional medicine, ginseng is revered as the 'king of herbs'. Ginseng has the effects of greatly tonifying vital energy, strengthening the spleen and benefiting the lungs, generating fluids and nourishing the blood, and calming the mind while enhancing intelligence.
View Article and Find Full Text PDFRole of ginsenoside Rg1 as a PPAR-γ activator in protecting against manganese-induced hepatotoxicity: Insights into the TLR4/MyD88/MAPK signaling pathway.
Ecotoxicol Environ Saf
December 2024
Department of Pharmacy, Chaohu Hospital of Anhui Medical University, China. Electronic address:
This study investigates the protective effect of ginsenoside Rg1 against manganese (Mn)-induced hepatotoxicity, highlighting its role as a PPAR-γ activator and its impact on TLR4/MyD88/MAPK pathway. Manganese induces liver damage through mechanisms involving oxidative stress and inflammation. Rg1, a principal bioactive compound of ginseng, significantly alleviates Mn-induced liver injury.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!