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Insulin and TLR4 Inhibitor Improve Motor Impairments in a Rat Model of Parkinson's Disease.
Iran J Pharm Res
June 2024
Pharmaceutical Sciences Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Background: Insulin resistance is an important pathological hallmark of Parkinson's disease (PD). Proinflammatory cytokines during neuroinflammation decrease insulin sensitivity by suppressing insulin signaling elements. Toll-like receptor 4 (TLR4), the main receptor involved in neuroinflammation, is also associated with the pathogenesis of PD.
View Article and Find Full Text PDFIntranasal insulin administration affecting perioperative neurocognitive dysfunction by regulating calcium transport protein complex IP3R/GRP75/VDAC1 on MAMs.
Free Radic Biol Med
January 2025
Department of Anesthesiology, The First Hospital of China Medical University, Shenyang, China. Electronic address:
Unlabelled: Perioperative neurocognitive disorders (PND) are common complications following surgery and anesthesia, especially in the elderly. These disorders are associated with disruptions in neuronal energy metabolism and mitochondrial function. This study explores the potential of intranasal insulin administration as a therapeutic strategy to prevent PND by targeting the calcium transport protein complex IP3R/GRP75/VDAC1 on mitochondria-associated endoplasmic reticulum membranes (MAMs).
View Article and Find Full Text PDFLaminar Fluid Ejection for Olfactory Drug Delivery: A Proof of Concept Study.
IEEE J Transl Eng Health Med
December 2024
Rocket Science Health Victoria BC V8V 2Y1 Canada.
Focal intranasal drug delivery to the olfactory cleft is a promising avenue for pharmaceuticals targeting the brain. However, traditional nasal sprays often fail to deliver enough medication to this specific area. We present a laminar fluid ejection (LFE) method for precise delivery of medications to the olfactory cleft.
View Article and Find Full Text PDFIntranasal insulin increases brain glutathione (GSH) and enhances antioxidant capacity in healthy participants, but not in those with early psychotic disorders.
Biol Psychiatry Cogn Neurosci Neuroimaging
November 2024
Psychotic Disorders Division, McLean Hospital, Belmont, MA, USA; Department of Psychiatry, Harvard Medical School, Boston, MA, USA.
Article Synopsis
- * Twenty-one patients and 18 controls underwent pre- and post-insulin cognitive and magnetic resonance spectroscopy (MRS) assessments to measure changes in brain metabolites.
- * Results showed that while intranasal insulin increased glutathione levels and improved cognitive performance in healthy participants, it did not have the same effect in individuals with early psychotic disorders.
Transmucosal glucagon rapidly increases blood glucose concentration in healthy cats.
J Feline Med Surg
November 2024
Department of Small Animal Clinical Sciences, University of Florida, College of Veterinary Medicine, Gainesville, FL, USA.
Objectives: To evaluate the effect of transmucosal glucagon powder (Baqsimi; Amphastar Pharmaceuticals) on blood glucose (BG) concentrations in healthy cats and describe adverse reactions to its administration.
Methods: A randomized, controlled, crossover study was conducted on six healthy cats with a 7-day washout period between treatments. Transmucosal glucagon powder was administered intranasally and rectally and compared with intranasal placebo.
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