103 chickens experimentally infected with Capillaria obsignata were treated with Mebendazol at a dose of 30 mg/kg body-weight daily for 3 consecutive days. The effectiveness of the drug on the 4th stage larvae as well as immature and mature 5th stage forms were 92,5%, 98% and 98,8% respectively. In another experiment to 32 chickens experimentally infected with Syngamus trachea Mebendazol was given at 40 mg/kg body-weight on 3 successive days. Mebendazol removed the immature and mature gape worms completely. The anthelmintic effect of Mebendazol was also tested at 18 geese naturally infected with Amidostomum anseris, Trichostrongylus tenuis, Capillaria anatis, Hymenolepis lanceolata and Hymenolepis setigera. The treatment removed nematode-infection completely at a dose of 10 mg/kg body-weight and cestode-infection at a dose of 30 mg/kg body-weight when given daily for 3 consecutive days. Two groups of geese, 20 in each group, were treated against Hymenolepis-infection using Mebendazol in food for 6 consecutive days. It was found that Mebendazol when given at a dose of 10 mg/kg body-weight for 6 days removed the infection partly, whereas 30 mg/kg body-weight eliminated the whole worm burden.
Download full-text PDF |
Source |
---|---|
http://dx.doi.org/10.1080/03079457309353785 | DOI Listing |
Dokl Biochem Biophys
January 2025
Department of Orthopaedics, Affiliated Hospital of Hebei University, 071000, Baoding, China.
Unlabelled: Osteoporosis is a condition where bones weaken due to a loss in density and quality, making them fragile and more susceptible to fractures, even from minor stress or injury. In this experimental study, we scrutinized the antiosteoporosis effect of phyllanthin against glycocorticoid (GIOP) induced osteoporosis in rats.
Methods: : SD rats were used in this study and subcutaneous administration of DEX (3 mg/kg) was used for the induction of osteoporosis and rats were treated with phyllanthin and alendronate for 12 weeks.
Pharm Res
January 2025
Department of Pharmaceutics, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, 160 Frelinghuysen Road, Piscataway, NJ, 08854, USA.
Purpose: To investigate how obesity affects the pharmacokinetics of biologics in a rat model.
Method: Male Long-Evans rats were fed a high-fat diet from the age of 3 weeks and development of obesity was monitored by measuring body size and composition (fat and lean mass). The animals received nivolumab (1 and 8 mg/kg) or recombinant human erythropoietin (rHuEPO, 1000 IU/kg) by intravenous or subcutaneous injection.
Background: Uncertainty about optimal tranexamic acid (TXA) dosage has led to significant practice variation in hip arthroplasty. We aimed to identify the optimal i.v.
View Article and Find Full Text PDFTissue Cell
January 2025
Karabuk University, Faculty of Medicine, Department of Medical Biochemistry, Karabuk, Turkey.
The research sought to assess the therapeutic impact of resveratrol by biochemical, immunohistochemical, and histopathological analyses in a TiO-induced liver fibrosis model. Titanium dioxide (100 mg/kg body weight) was delivered for 15 days to induce liver fibrosis, either alone or in conjunction with resveratrol (30 mg/kg body weight) therapy for the same duration. Resveratrol has been identified as a crucial therapeutic drug that provides an alternative treatment method for TiO-induced liver fibrosis by mitigating inflammation, oxidative stress, and the expressions of α-SMA and 8-OHdG.
View Article and Find Full Text PDFDokl Biochem Biophys
January 2025
Affiliated Hospital of Hebei University, 071000, Baoding City, Hebei Province, China.
Unlabelled: . Renal cell carcinoma (RCC) is the most prevalent form of kidney cancer and is the primary malignancy affecting the genitourinary system. It represents the majority of kidney cancer cases and is distinguished by its aggressive nature and high mortality rate.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!