AI Article Synopsis
- N-hydroxycytosine nucleoside 3 was created as a potential treatment for Hepatitis C Virus (HCV).
- The synthesis process began with D-ribose and involved several key reactions, including an iodine-fluorine exchange, RCM reaction, stereoselective reduction, and Mitsunobu reaction.
- BuLi (butyllithium) was utilized as a crucial reagent in the synthesis steps.
Article Abstract
N-hydroxycytosine nucleoside 3 was synthesized as potential anti-HCV agent, starting from D-ribose using an iodine-fluorine exchange reaction by a help of BuLi, a RCM reaction, a stereoselective reduction and a Mitsunobu reaction as the key steps.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1093/nass/nrn307 | DOI Listing |
Publication Analysis
Top Keywords
potential anti-hcv
8
anti-hcv agent
8
synthesis pyrimidine
4
pyrimidine analog
4
analog fluoroneplanocin
4
fluoroneplanocin potential
4
agent n-hydroxycytosine
4
n-hydroxycytosine nucleoside
4
nucleoside synthesized
4
synthesized potential
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!