Click chemistry and oligonucleotides: how a simple reaction can do so much.

Nucleic Acids Symp Ser (Oxf)

IBMM, UMR5247 CNRS Université Montpellier 1, Université Montpellier 2, Place E. Bataillon, CC1704, 34095 Montpellier Cedex 5, France.

Published: November 2010

Copper catalyzed Alkyne Azide 1,3-dipolar cycloaddition (CuAAC) "click reaction" was applied for the construction of oligonucleotide conjugates, circular objects and phosphodiester glyco-clusters. To this end, several strategies were developed to introduce either alkyne or azide functions into an oligonucleotide.

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Source
http://dx.doi.org/10.1093/nass/nrn024DOI Listing

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