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Idd9/11 genetic locus regulates diabetogenic activity of CD4 T-cells in nonobese diabetic (NOD) mice. | LitMetric

AI Article Synopsis

  • The study investigates the role of non-MHC susceptibility genes in protecting NOR mice from developing type 1 diabetes, despite sharing the same H2(g7) MHC with NOD mice.
  • Through various experiments, the researchers found that CD4 T-cells from NOR mice are less capable of causing diabetes compared to those from NOD mice, attributed to intrinsic factors that modulate their activity.
  • Specifically, the Idd9/11 resistance region on chromosome 4 was identified as a regulatory factor that reduces the pathogenicity of CD4 T-cells, highlighting its potential importance in autoimmune diabetes resistance.

Article Abstract

Objective: Although the H2(g7) major histocompatibility complex (MHC) provides the primary pathogenic component, the development of T-cell-mediated autoimmune type 1 diabetes in NOD mice also requires contributions from other susceptibility (Idd) genes. Despite sharing the H2(g7) MHC, the closely NOD-related NOR strain remains type 1 diabetes resistant because of contributions of protective Idd5.2, Idd9/11, and Idd13 region alleles. To aid their eventual identification, we evaluated cell types in which non-MHC Idd resistance genes in NOR mice exert disease-protective effects.

Research Design And Methods: Adoptive transfer and bone marrow chimerism approaches tested the diabetogenic activity of CD4 and CD8 T-cells from NOR mice and NOD stocks congenic for NOR-derived Idd resistance loci. Tetramer staining and mimotope stimulation tested the frequency and proliferative capacity of CD4 BDC2.5-like cells. Regulatory T-cells (Tregs) were identified by Foxp3 staining and functionally assessed by in vitro suppression assays.

Results: NOR CD4 T-cells were less diabetogenic than those from NOD mice. The failure of NOR CD4 T-cells to induce type 1 diabetes was not due to decreased proliferative capacity of BDC2.5 clonotypic-like cells. The frequency and function of Tregs in NOD and NOR mice were also equivalent. However, bone marrow chimerism experiments demonstrated that intrinsic factors inhibited the pathogenic activity of NOR CD4 T-cells. The NOR Idd9/11 resistance region on chromosome 4 was found to diminish the diabetogenic activity of CD4 but not CD8 T-cells.

Conclusions: In conclusion, we demonstrated that a gene(s) within the Idd9/11 region regulates the diabetogenic activity of CD4 T-cells.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2584133PMC
http://dx.doi.org/10.2337/db08-0767DOI Listing

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