The purpose of this study was to evaluate in a controlled study the effect of exogenous surfactant on various manifestations of ductal patency. Premature infants with respiratory distress syndrome were randomized to receive surfactant (Survanta) (n = 22) or air (n = 14). In neonates receiving surfactant, there was a greater tendency for an audible murmur to develop (13 of 22 vs four of 14). In spite of this, the clinical use of indomethacin was similar for the two groups, 10 (45%) of 22 vs six (43%) of 14. Excluding neonates given indomethacin early, a comparable number of surfactant-treated neonates (9/17 [53%]) vs control neonates (6/12 [50%]) demonstrated spontaneous closure of the ductus within a physiologic time frame (on or before day 4). For the gestational ages studied, the beneficial effects of exogenous surfactant were not associated with either an increased risk for delayed closure of the ductus arteriosus or a greater incidence of indomethacin usage. Utilization of exogenous surfactant does not appear to have an adverse impact on ductal patency.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1001/archpedi.1991.02160090069025 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Fetal-to-Neonatal Transition of an Infant with Transposition of the Great Arteries and Intact Ventricular Septum: A Case Report.
Biomed Hub
December 2024
Division of Paediatric Cardiology, Department of Paediatrics, Willem-Alexander Children's Hospital, Leiden University Medical Centre (LUMC), Leiden, The Netherlands.
Introduction: Transposition of the great arteries (TGA), especially with intact ventricular septum (TGA-IVS), presents unique challenges during fetal-to-neonatal transition, which can contribute to developing persistent pulmonary hypertension of the newborn (PPHN).
Case Presentation: A male newborn with TGA-IVS, delivered via caesarean section, presented with hypoxemia and tachycardia immediately after birth (preductal SpO: 50-60%, post-ductal SpO: 70-75%). Echocardiography revealed a floppy interatrial septum and two interatrial connections with bidirectional shunting.
Practice variation using the hybrid stage I procedure in congenital heart disease: Results from a national survey.
JTCVS Open
October 2024
Division of Pediatric Cardiology, Department of Pediatrics, University of Michigan, Ann Arbor, Mich.
Article Synopsis
- Hybrid stage I palliation is a procedure used mainly for high-risk patients with single ventricle heart disease, serving various roles such as a starter treatment or a bridge to more complex surgeries or transplants.
- A survey sent to congenital heart centers in the U.S. and Canada revealed that about 45 out of 106 centers perform this type of palliation, with a majority using pulmonary artery bands and ductal stents for management.
- There is significant variation in the practices and indications for hybrid stage I palliation among centers, highlighting the need for multicenter studies to establish standardized protocols and improve patient outcomes.
[Incidental discovery of a patent ductus arteriosus in adults].
Rev Med Liege
October 2024
Service de Cardiologie, CHU Liège, Belgique.
The patent ductus arteriosus is a vascular structure that connects the proximal descending aorta to the main pulmonary artery near the origin of the left pulmonary artery. The persistence of ductal patency after the first weeks of life is abnormal. In adults, it is most often an isolated finding but it may be associated with other congenital anomalies.
View Article and Find Full Text PDFSpatial Transcriptomics Unravel the Tissue Complexity of Oral Pathogenesis.
J Dent Res
December 2024
Department of Oral Biology, College of Dentistry, University of Illinois Chicago, Chicago, IL, USA.
Article Synopsis
- Spatial transcriptomics (ST) is a novel technique that combines gene expression profiling with spatial information in tissue sections, providing insight into cellular relationships in health and disease.* -
- The methodology is applied to various craniofacial regions and diseases, uncovering crucial spatial patterns, gene expressions, and autoimmunity insights in conditions like Sjögren's disease and oral cancers.* -
- ST enhances our understanding of complex biological interactions and disease mechanisms, revealing critical gene signatures related to development, immune responses, and tissue-specific conditions.*
Long-Term Patency Rates of Portal Vein/Superior Mesenteric Vein Reconstruction after Pancreatic Resection for Pancreatic Tumors: Single-Center Experience.
Life (Basel)
September 2024
Department of Surgical Oncology, National Cancer Institute Bratislava, Klenova 1, 833 10 Bratislava, Slovakia.
To achieve an R0 resection margin in patients with locally advanced pancreatic ductal adenocarcinoma, high-volume pancreatic centers standardly incorporate portal vein or superior mesenteric vein resection. However, there is currently no consensus on the optimal reconstructive approach. Postoperative venous thrombosis or stenosis can significantly increase patient morbidity or mortality.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!