The synthesis of (-)-hamigeran B has been achieved, based on a new approach to cyclopentane construction, the rhodium-mediated intramolecular C-H insertion of alpha-aryl-alpha-diazoketones. The endo-isopropyl group was installed by selective hydrogenation of a cyclopropylidene substituent.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2626181 | PMC |
| http://dx.doi.org/10.1021/jo8010683 | DOI Listing |
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