AI Article Synopsis
- Researchers used electro-olfactogram recording to investigate if adult rainbow trout's olfactory epithelium is sensitive to bile acids, which may act as pheromones.
- Of the 38 bile acids tested for olfactory activity, 6 were selected, with taurocholic acid (TCA) and taurolithocholic acid 3-sulfate (TLS) showing the strongest effects.
- Cross-adaptation experiments indicated that sensitivity to bile acids involves at least three different olfactory receptor types, supporting the idea that these compounds are detected by rainbow trout and could serve as pheromones.
Article Abstract
Electro-olfactogram recording was used to determine whether the olfactory epithelium of adult rainbow trout is specifically sensitive to bile acids, some of which have been hypothesized to function as pheromones. Of 38 bile acids that had been pre-screened for olfactory activity, 6 were selected. The rainbow trout-specific bile acids, taurocholic acid (TCA), and taurolithocholic acid 3-sulfate (TLS) were the most potent compounds tested. TLS had a distinctive dose-response curve. Cross-adaptation experiments demonstrated that sensitivity to bile acids is attributable to at least 3 independent classes of olfactory receptor sites. Our data suggest that bile acids are discriminated by olfaction in rainbow trout, supporting the possibility that these compounds function as pheromones.
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