Cohesin is a large ring-shaped protein complex that mediates cohesion between sister chromatids. New experiments show that the sister chromatids of a minichromosome are entrapped by monomeric cohesin rings, thus excluding the possibility that sister chromatid cohesion is mediated by nontopological interactions between cohesin complexes.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2956263PMC
http://dx.doi.org/10.1038/nsmb0908-899DOI Listing

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