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| http://dx.doi.org/10.1161/HYPERTENSIONAHA.108.117770 | DOI Listing |
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A Copper-Binding Peptide with Therapeutic Potential against Alzheimer's Disease: From the Blood-Brain Barrier to Metal Competition.
ACS Chem Neurosci
December 2024
Department of Chemistry, Center for Research and Advanced Studies (Cinvestav), Mexico City 07360, Mexico.
Alzheimer's disease (AD) is the most common form of dementia worldwide. AD brains are characterized by the accumulation of amyloid-β peptides (Aβ) that bind Cu and have been associated with several neurotoxic mechanisms. Although the use of copper chelators to prevent the formation of Cu-Aβ complexes has been proposed as a therapeutic strategy, recent studies show that copper is an important neuromodulator that is essential for a neuroprotective mechanism mediated by Cu binding to the cellular prion protein (PrP).
View Article and Find Full Text PDFSecondary sphere interactions modulate peroxynitrite scavenging by the E2 domain of amyloid precursor protein.
Dalton Trans
January 2025
Department of Chemistry, Purdue University, West Lafayette, Indiana 47906, USA.
Peroxynitrite (ONOO) is a highly reactive nitrogen species that can cause significant damage to proteins, lipids, and DNA. Various enzymes, including metalloenzymes, play crucial roles in reducing ONOO concentrations to protect cellular components. While the interaction of ONOO with heme proteins is well known, the reduction by Cu-containing proteins is less studied.
View Article and Find Full Text PDFSolving the puzzle of copper trafficking in Trypanosoma cruzi: candidate genes that can balance uptake and toxicity.
FEBS J
December 2024
Instituto de Biología Molecular y Celular de Rosario (IBR), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET)-Universidad Nacional de Rosario (UNR), Rosario, Argentina.
Article Synopsis
- Trypanosoma cruzi, the parasite causing Chagas disease, relies on copper (Cu) for growth and development, but its levels must be carefully controlled due to potential toxicity.
- The study found that Cu is crucial for the proliferation of the epimastigote stage and the transition to the metacyclic form, but the intracellular amastigote stage experiences copper stress during infection.
- Researchers identified key gene products related to copper metabolism, such as TcCuATPase for copper export and suggested TcIT as a possible copper importer, highlighting a unique model of copper transport and distribution in T. cruzi.
Noncanonical Amino Acid Tools and Their Application to Membrane Protein Studies.
Chem Rev
November 2024
Faculty of Life Science, Institute of Biochemistry, Leipzig University, Leipzig 04103, Germany.
Article Synopsis
- Methods in chemical biology, specifically genetic code expansion (GCE), have greatly improved the study of integral membrane proteins by allowing the incorporation of noncanonical amino acids (ncAAs).
- GCE is particularly challenging for membrane proteins due to their unique characteristics and low expression levels, requiring effective use of mammalian cell cultures for functional expression.
- Recent advancements include engineered AARS/tRNA pairs for better performance in mammalian cells, bioorthogonal reactions for attaching probes to live cell membrane proteins, and an expanded selection of ncAAs for in-depth analysis of protein structure and dynamics.
Zinc-modulated bidirectional copper transfer across the blood-brain barrier in a porcine brain capillary endothelial cell culture model system.
J Trace Elem Med Biol
December 2024
Trace-Age-DFG Research Unit on Interactions of Essential Trace Elements in Healthy and Diseased Elderly (FOR 2558), Berlin-Potsdam-Jena-Wuppertal, Nuthetal 14558, Germany; German Federal Institute for Risk Assessment (BfR), Berlin 10589, Germany. Electronic address:
The blood-brain barrier (BBB) serves as a crucial interface, regulating the transfer of trace elements (TEs) such as copper (Cu) and zinc (Zn) between the bloodstream and the brain. Cu and Zn are essential for maintaining neural function and enzymatic processes. Understanding the interplay of Cu and Zn with the BBB is crucial for elucidating their roles in neurological health and disease.
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