Objectives: The gastro-esophageal reflux disease is responsible of oto-rhino-laryngological symptoms included dysphonia. We studied the relationship between reflux disease and dysphonia. The research for the prevalence of reflux disease, in a dysphonic population, has been performed by a clinical and laryngoscopic survey.
Methods: 175 patients were included prospectively. Each patient replies to the questionnaire and see the physician to do a laryngoscopic examination during the same time. A physician jury sees all videos to determine gastro-oesophagial reflux disease laryngoscopic signs.
Results: Statistically significant correlations were found for vocal oedema and posterior hypertrophia in relation with reflux.
Conclusion: We have pointed out that laryngoscopy is not an adequate diagnosis tool, because it is operator dependant. Nevertheless the diagnosis of gastro-esophageal reflux disease, regarding the vocal symptoms, is proposed when associated with clinic reflux signs (pyrosis).
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Prokinetic agents are drugs used to enhance gastrointestinal motility and treat disorders such as Gastroesophageal Reflux Disease (GERD) and gastroparesis. pH-dependent release systems offer targeted drug delivery, allowing prokinetic agents to be released specifically in desired regions of the gastrointestinal tract. This optimizes drug efficacy and minimizes systemic side effects.
View Article and Find Full Text PDFSurg Laparosc Endosc Percutan Tech
January 2025
Department of Surgery, Division of Gastrointestinal Surgery, University of South Florida, Morsani College of Medicine, Tampa, FL.
Background And Aims: Several studies have hypothesized that sparing the oblique/sling fibers during posterior peroral endoscopic myotomy (POEM) may reduce the incidence of gastroesophageal reflux disease (GERD) and reflux esophagitis without compromising the established safety and efficacy of the procedure. This study compares perioperative, postoperative motility-related, and postoperative GERD-related outcomes between posterior oblique/sling fibers-sparing POEM (OFS-POEM) and conventional posterior POEM through a pairwise meta-analysis of comparative studies.
Methods: We conducted a systematic literature review following PRISMA guidelines to identify articles directly comparing posterior OFS-POEM with conventional posterior POEM.
Prz Gastroenterol
December 2024
Department of Pathology, Detagen Pathology Laboratory, Kayseri, Turkey.
Introduction: Gastroesophageal reflux disease (GERD) is a common disease that negatively affects the quality of life, and its pathophysiology is multifactorial.
Aim: Our study aims to investigate the relationship between histological and topographic characteristics of () gastritis and the symptoms, presence, and severity of oesophagitis in patients with reflux symptoms.
Material And Methods: The symptoms, demographic data, and physical examination results of the patients admitted with gastrointestinal complaints were recorded and oesophagogastroduodenoscopies were performed.
Prz Gastroenterol
May 2024
Department of Allergology, Clinical Immunology, and Internal Diseases, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun, Jan Biziel University Hospital No. 2 in Bydgoszcz, Poland.
Eosinophilic esophagitis (EoE) is a chronic immune-mediated esophageal disease, clinically characterised by symptoms of esophageal dysfunction and histologically by eosinophilic infiltration of its wall. The last 3 decades have seen a sharp increase in its incidence to the point that it is called the second most common esophageal disease after reflux disease in some recent studies. The main indicators of EoE are food allergens and in recent years the extremely important role of oral immunotherapy (OIT) in the development of this disease has also been increasingly raised.
View Article and Find Full Text PDFCommun Biol
January 2025
College of Medical Information and Artificial Intelligence, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, Shandong, P. R. China.
Digestive and psychiatric disorders tend to co-occur, yet mechanisms remain unclear. Leveraging genetic and transcriptomic data integration, we conduct multi-trait analysis of GWAS (MTAG) and weighted gene co-expression network analysis (WGCNA) to explore shared mechanism between psychiatric and gastrointestinal disorders. Significant genetic correlations were found between these disorders, especially in irritable bowel syndrome (IBS), gastroesophageal reflux disease (GERD), depression (DEP), and neuroticism (NE).
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