Background: Our aim was to review our experience with liposarcoma of the head and neck region.
Methods: This is a retrospective case series at a comprehensive cancer center (1945-2005).
Results: Of 30 patients, 10 (33%) were initially misdiagnosed. Local recurrences were common (overall rate = 53%), and 4 patients (13%) developed distant metastases. Decreased crude disease-specific survival rates were significantly associated with recurrence (especially distant recurrence [0%]), age less than 38 years (40%), and pleomorphic subtype (45%); however, in Kaplan-Meier analyses, only larger tumor size, negative margins, round cell subtype, and pleomorphic subtype were associated with significantly decreased disease-specific survival (log-rank test p = .048, .041, .021, and .012, respectively).
Conclusions: Based on this limited experience and existing literature, we continue to recommend surgery with negative margins as the treatment of choice and that adjuvant therapies should be considered in patients with high-grade histology, large tumors, positive margins, or certain subsites.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1002/hed.20923 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Novel Therapeutics in Soft Tissue Sarcoma.
Cancers (Basel)
December 2024
Sarcoma Unit, The Royal Marsden Hospital and Institute of Cancer Research, London SW3 6JZ, UK.
There has been noteworthy progress in molecular characterisation and therapeutics in soft tissue sarcomas. Novel agents have gained regulatory approval by the FDA. Examples are the tyrosine kinase inhibitors avapritinib and ripretinib in gastrointestinal stromal tumours (GIST), the immune check point inhibitor atezolizumab in alveolar soft part tissue sarcoma, the γ-secretase inhibitor nirogacestat in desmoid tumours, the NTRK inhibitors larotrectinib and entrectinib in tumours with fusions, the mTOR inhibitor nab-sirolimus in PEComa, and the EZH-2 inhibitor tazemetostat in epithelioid sarcoma.
View Article and Find Full Text PDFPhenotypic plasticity in parotid tumours: insights from a surgical oncologist's perspective.
BMJ Case Rep
December 2024
Pathology, Army Hospital Research and Referral, New Delhi, India.
Article Synopsis
- - Phenotypic plasticity in tumor cells allows them to adapt and change due to stressors, playing a key role in tumor progression, as illustrated by a case of a 70-year-old man with pleomorphic adenoma who developed pleomorphic liposarcoma.
- - Sarcomas, like liposarcoma, can develop from existing pleomorphic adenomas in the parotid gland, with only a few documented cases of primary parotid liposarcoma.
- - This case report examines the uncharted adenoma-carcinoma-sarcoma progression in pleomorphic adenomas, aiming to provide insights for treatment planning and management from a surgical oncology standpoint.
Liposarcoma of Maxilla- A Rare Case Report.
Indian J Otolaryngol Head Neck Surg
December 2024
Gujarat Cancer and Research Institute, Shahibaug, Ahmedabad, Gujarat, India.
Introduction: Sarcomas of the head and neck region account for less than 10% of soft tissue sarcomas, and comprise less than 1% of head and neck malignancies. Approximately 80% of sarcomas arise from soft tissue, with the remaining originating from bone or cartilage. Head and neck sarcomas typically occur more frequently in men.
View Article and Find Full Text PDFWell-Differentiated Liposarcoma of the Posterior Neck: A Case Report.
Cureus
August 2024
Otolaryngology, Head and Neck Surgery, Farwaniya Hospital, Al Farwaniyah, KWT.
Article Synopsis
- Soft tissue sarcoma, although rare, should be considered when evaluating masses in the head and neck regions, requiring careful assessment.
- A patient with a suspected intermuscular lipoma in the neck underwent imaging, which indicated a large fatty mass, but post-surgery, it was diagnosed as a well-differentiated liposarcoma after histopathological examination.
- The case highlights the importance of thorough diagnosis and treatment strategies for conditions that can be misidentified, showcasing the details involved in the surgical approach to remove the mass.
Lateral hypopharyngectomy with laryngeal preservation reconstructed with inlay fascio-cutaneous free flaps: clinical and functional outcomes.
Acta Otorhinolaryngol Ital
December 2024
Unit of Otorhinolaryngology - Head and Neck Surgery, ASST Spedali Civili of Brescia, Brescia, Italy.
Article Synopsis
- Lateral hypopharyngectomy (LH) is a surgical method aimed at treating certain early-stage squamous cell carcinoma and other rare tumors, focusing on preserving the organ while managing complex cases of recurring cancer with various reconstruction techniques.* -
- A study reviewed patients who underwent LH between 2017 and 2023, looking at their clinical histories and outcomes; 71% had recurrent diseases, and most achieved negative surgical margins, with a successful swallowing rehabilitation for almost all patients post-surgery.* -
- The findings suggest that LH, combined with free flap reconstruction, can effectively and safely remove certain hypopharyngeal tumors while maintaining good functional and oncological results, evidenced by the survival of most patients after an average
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!