Biochemical and histopathological changes in experimental nephrotoxic serum nephritis in chickens were studied. Immunofluorescence studies revealed linear deposits of IgG along the glomerular basement membrane with monospecific anti-rabbit IgG and monospecific anti-chicken IgG during heterologous and autologous phases of disease, respectively. The overall histopathological picture was of proliferative glomerulonephritis. Proliferative lesions of an equal or even greater severity were observed in chickens without IgG deposits on the glomerular basement membrane. Ultrastructurally, mesangium revealed hyperplasia. Glomerular basement membrane appeared thickened but prodocytes were normal.
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