AI Article Synopsis
- FFRs are neural responses that capture low-frequency sounds and are generated in the inferior colliculus, which is part of the auditory pathway in the brain.
- The study found that in anesthetized rats, presenting pure tones (225-4025 Hz) to one ear (ipsilateral) successfully elicited these responses.
- Blocking glutamate (which helps with signals between neurons) in one side of the inferior colliculus reduced these FFRs, while blocking another area (the contralateral dorsal nucleus of the lateral lemniscus) actually enhanced them, indicating a complex interaction between excitatory and inhibitory signals in the processing of sound.
Article Abstract
Auditory frequency-following responses (FFRs) are sustained potentials based on phase-locked neural activity preserving low-frequency information. Some neurons in rat inferior colliculus are excited by stimuli at either ear. This study shows that FFRs in inferior colliculus can be elicited by presenting pure tone bursts with frequencies from 225 to 4025 Hz at the ipsilateral ear in anesthetized rats. Moreover, chemical block of glutamate transmissions in the contralateral inferior colliculus markedly reduced the ipsilaterally driven FFRs, which, however, were significantly enhanced by blocking the contralateral dorsal nucleus of the lateral lemniscus. Thus, FFRs in inferior colliculus to ipsilateral stimulation were facilitated by excitatory projections from the contralateral inferior colliculus but suppressed by inhibitory projections from the contralateral dorsal nucleus of the lateral lemniscus.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1097/WNR.0b013e32830c1cfa | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!