The inhibitory effect of dichlorovos (an organophosphate pesticide) on Ca(2+)-dependent contractions has been studied in isolated helical strips of rat tail arteries. Isometric contractions were evaluated under standard organ bath conditions. Dichlorovos caused concentration-dependent relaxation of 10(-7) M NE-induced contractions as well as inhibition of both phasic and tonic components of NE contractions. Extracellular calcium-dependent contractions in K(+)-depolarized medium as well as NE-induced contractions due to mobilization of membrane-bound calcium pool and intracellular calcium-dependent caffeine contractions were significantly attenuated by dichlorovos. The results strongly support our previous observation that dichlorovos interferes with calcium metabolism in the rat tail artery.
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