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Myocardial synchronized exercise and prognosis in patients with heart failure with preserved ejection fraction assessed by two-dimensional ultrasound speckle tracking stratified strain imaging.
Medicine (Baltimore)
January 2025
Department of Ultrasound, JinHua Municipal Central Hospital, Jinhua, Zhejiang, China.
To evaluate myocardial synchronized exercise and clinical prognosis in patients with heart failure preserved ejection fraction (HFpEF), we utilized two-dimensional speckle tracking (2D-STI) stratified strain imaging. We retrospectively summarized 146 patients diagnosed with HFpEF in our hospital from January 2022 to January 2023. 2D-STI combined with stratified strain imaging was used to measure the overall left ventricular global longitudinal strain (LVGLS), the sub-endocardium, mid-myocardium, sub-epicardium LS of the left ventricle, as well as the basal, intermediate, and apical LS, the peak strain dispersion (PSD) and the transmural pressure difference, the postsystolic shortening (PSS), and early systolic lengthening.
View Article and Find Full Text PDFA Drosophila cardiac myosin increases jump muscle stretch activation and shortening deactivation.
Biophys J
January 2025
Department of Biological Sciences & Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute Troy, NY 12180, USA; Department of Biomedical Engineering, Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute Troy, NY 12180, USA. Electronic address:
Stretch activation (SA), a delayed increase in force production following rapid muscle lengthening, is critical to the function of vertebrate cardiac muscle and insect asynchronous indirect flight muscle (IFM). SA enables or increases power generation in muscle types used in a cyclical manner. Recently, myosin isoform expression has been implicated as a mechanism for varying the amplitude of SA in some muscle types.
View Article and Find Full Text PDFAmphetamine Injection into the Nucleus Accumbens and Electrical Stimulation of the Ventral Tegmental Area in Rats After Novelty Test-Behavioral and Neurochemical Correlates.
Int J Mol Sci
December 2024
Department of Animal and Human Physiology, Faculty of Biology, University of Gdansk, 59 Wita Stwosza Str., 80-308 Gdansk, Poland.
Amphetamine abuse is a global health epidemic that is difficult to treat due to individual differences in response to environmental factors, including stress reactivity and anxiety levels, as well as individual neuronal differences, which may result in increased/decreased vulnerability to addiction. In the present study, we investigated whether the Wistar rats behavioral traits of high (HR) and low (LR) locomotor activity to novelty influence motivational behavior (induced feeding model; iFR by electrical stimulation of the ventral tegmental area; Es-VTA) supported by amphetamine injection into the nucleus accumbens shell (AcbSh) (HR, n = 5; LR, n = 5). A correlation was found between the novelty test's locomotor activity score and the frequency threshold percentage change ( < 0.
View Article and Find Full Text PDFUp-regulation of miR-490-3p improves learning/memory disability of sevoflurane exposure by relieving neuroinflammation.
Toxicol Res (Camb)
January 2025
Department of Anaesthesia and Surgery, Shengli Oilfield Central Hospital, Dongying 257034, China.
Our study focused on the potential mechanism of microRNA-490-3p (miR-490-3p) on learning/memory disability of rats resulting from sevoflurane (Sev). The rat model of cognitive dysfunction was established by infection with miR-490-3p mimic and Sev-exposure. Morris water maze and open field test assay were used for the assessment of cognitive deficits.
View Article and Find Full Text PDFShort-term outcomes of gradual ulnar lengthening in multiple hereditary osteochondromas of the forearm with monolateral external fixator.
J Pediatr Orthop B
January 2025
Trauma Research Center, Rajaee (Emtiaz) Trauma Hospital, Shiraz University of Medical Sciences, Shiraz, Iran.
Hereditary multiple exostoses is an autosomal dominant genetic condition primarily affecting long bones. Forearm deformities, including wrist ulnar deviation, ulnar shortening, radial or ulnar bowing, and radial head dislocation, are common manifestations. Gradual ulnar lengthening is suggested as a viable treatment option for managing these deformities.
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