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Immunohistochemical expression of the glucose transporters Glut-1 and Glut-3 in human malignant melanomas and benign melanocytic lesions. | LitMetric

AI Article Synopsis

  • Cancer cells have higher glucose metabolism rates, with Glut-1 transporter expression being notably increased in various malignancies.
  • A study used tissue samples from different types of melanocytic lesions to assess the expression of Glut-1 and Glut-3.
  • Results showed Glut-1 was primarily found in benign nevi, while its expression was reduced in many malignant melanomas, indicating its potential as a discriminator between benign and malignant lesions.

Article Abstract

Background: Reported data indicate that cancer cells have increased rates of glucose metabolism, as determined by 18FDG-PET imaging in patients with malignancies. The results of many studies have demonstrated that the expression of glucose transporters, especially Glut-1, is increased in a variety of malignancies. This study was undertaken to assess the differential expression of Glut-1 and Glut-3 by benign and malignant melanocytic lesions.

Methods: Immunohistochemical staining for Glut-1 and Glut-3 was performed on paraffin-embedded tissue sections prepared from melanocytic nevi (12 cases), Spitz nevi (12 cases) and primary cutaneous malignant melanomas (20 cases).

Results: We observed immunoreactivity for Glut-1 in all melanocytic nevi, 9 of the 12 Spitz nevi and in 9 of the 20 malignant melanomas, whereas Glut-3 was expressed in all the melanocytic lesions, both benign and malignant.

Conclusion: These findings indicate that the glucose transporters Glut-1 and Glut-3 play a role in the glucose metabolism of melanocytic cells. Glut-1 was present in the majority of benign nevi, whereas its expression was downregulated in 55% of malignant melanomas. Our results suggest that glucose transporter Glut-1 expression can significantly discriminate between human malignant melanoma and benign melanocytic nevi, and support the idea that additional mechanisms other than Glut-1 may contribute to glucose uptake in melanomas.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2553059PMC
http://dx.doi.org/10.1186/1756-9966-27-34DOI Listing

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