Study Objective: It is estimated that the prevalence rate of latent tuberculosis infection (LTBI) for the United States general population is less than 5%. The prevalence of LTBI among Connecticut migrant workers has not been reported. This study was designed to determine the prevalence of a positive tuberculin skin test (TST), a potential measure of LTBI in migrant workers, at one Connecticut farm.
Methods: A two-step standardized TST was performed on farmworkers recruited in a migrant clinic setting. Those with negative results on the first-step were offered the second. Workers with positive results were referred to community health centers for assessment and examined by a physician investigator.
Results: Seventy-nine male workers were recruited from a population of approximately 200. Of these, 57 consented to the first-step TST, and 26% tested positive. Over 96% of the 57 tested workers were from Mexico. None had symptoms or signs of active tuberculosis.
Conclusion: This study suggests that a high percentage of asymptomatic Connecticut Latino migrant farmworkers have LTBI. This finding has public health implications for TB control strategies in the state.
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Ann Clin Lab Sci
November 2024
Foundation for Advancement of Essential Diagnostics, Guwahati, Assam, India
Tuberculosis (TB) poses a significant public health challenge in India. According to the World Health Organization (WHO), India tops the list of 30 countries responsible for 87% of global TB cases in 2023. Recent data indicates that India's TB incidence rate was 195 cases per 100,000 population in 2023, accounting for approximately 26% of global TB cases.
View Article and Find Full Text PDFMycobacterium tuberculosis (M.tb) infection can lead to various outcomes, including active tuberculosis or latent tuberculosis infection (LTBI). Household contacts of TB cases have a high risk of acquiring LTBI.
View Article and Find Full Text PDFEmerg Microbes Infect
January 2025
Key Laboratory of Jiangxi Province for Transfusion Medicine, Department of Blood Transfusion, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi 330006, China.
The tRNA-derived small RNAs (tsRNAs) are a new class of non coding RNAs, which are stable in body fluids and can be used as potential biomarkers for disease diagnosis. However, the exact value of tsRNAs in the diagnosis of tuberculosis (TB) is still unclear. The objective of the present study was to evaluate the performance of the serum tsRNAs biosignature to distinguish between active TB, healthy controls, latent TB infection, and other respiratory diseases.
View Article and Find Full Text PDFJ Am Acad Dermatol
January 2025
Department of Dermatology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. Electronic address:
Front Immunol
January 2025
Division of Infectious Diseases, Department of Internal Medicine, State Key Laboratory of Complex Severe and Rare Disease, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Objective: This study aims to evaluate the diagnostic accuracy of a (MTB)-specific triple-color FluoroSpot assay (IFN-γ/IL-2/TNF-α) in the differentiation of tuberculosis (TB) infection status in febrile patients.
Method: Febrile patients with suspected active TB (ATB) were consecutively enrolled. The frequencies and proportions of MTB-specific T cells secreting IFN-γ, IL-2, and TNF-α were detected at the single-cell level by triple-color FluoroSpot assay.
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