The development of a new method for the assembly of unsymmetrical carbazoles is reported. The strategy involves the selective intramolecular functionalization of an arene C-H bond and the formation of a new arene C-N bond. The substitution pattern of the carbazole product can be controlled by the design of the biaryl amide substrate, and the method is compatible with a variety of functional groups. The utility of the new protocol was demonstrated by the concise synthesis of three natural products from commercially available materials.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2748774 | PMC |
| http://dx.doi.org/10.1021/jo801273q | DOI Listing |
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