AI Article Synopsis
- Intra-nucleus accumbens infusion of scopolamine significantly decreased fat intake triggered by the mu-opioid receptor agonist DAMGO during both 30 min and 4-hour pretreatment intervals.
- Scopolamine also lowered food intake in rats that were food-deprived, but did not affect water intake in those that were water-deprived.
- These findings suggest that muscarinic activity in the nucleus accumbens may specifically influence feeding behavior through interactions with the opioid system in the brain.
Article Abstract
Intra-nucleus accumbens (Acb) infusion of cholinergic muscarinic antagonist, scopolamine (10 microg/0.5 microl), markedly reduced fat intake elicited by intra-Acb treatment of the mu-opioid receptor agonist, DAMGO, with 30 min and 4h pretreatment intervals. Intra-Acb scopolamine infusions also reduced food intake in food-deprived rats, but not water intake in water-deprived rats. Hence, Acb muscarinic manipulations exhibit some specificity for feeding, perhaps via interactions with the striatal opioid system.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2657318 | PMC |
| http://dx.doi.org/10.1016/j.bbr.2008.08.002 | DOI Listing |
Publication Analysis
Top Keywords
muscarinic receptor
4
receptor antagonism
4
antagonism functional
4
functional alteration
4
alteration nucleus
4
nucleus accumbens
4
accumbens mu-opiate-mediated
4
mu-opiate-mediated feeding
4
feeding behavior
4
behavior intra-nucleus
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!