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S100A8/A9 innate immune signaling as a distinct mechanism driving progression of smoking-related breast cancers.
Oncogene
January 2025
Department of Pathology, University of California, San Diego, La Jolla, USA.
Smoking plays an underappreciated role in breast cancer progression, increasing recurrence and mortality in patients. Here, we show that S100A8/A9 innate immune signaling is a molecular mechanism that identifies smoking-related breast cancers and underlies their enhanced malignancy. In contrast to acute exposure, chronic nicotine increased tumorigenicity and reprogrammed breast cancer cells to express innate immune response genes.
View Article and Find Full Text PDFAssessing the impact of device parameters on electronic cigarette aerosol dynamics: Comprehensive analysis of emission profiles and toxic chemical constituents.
Sci Total Environ
January 2025
Department of Environment & Energy, Jeonbuk National University, 567 Baekje-daero, Deokjin-gu, Jeonju-si, Jeonbuk State 54896, Republic of Korea; School of Civil, Environmental, Resources and Energy Engineering, Jeonbuk National University, 567 Baekje-daero, Deokjin-gu, Jeonju-si, Jeonbuk State 54896, Republic of Korea; Soil Environment Research Center, Jeonbuk National University, 567 Baekje-daero, Deokjin-gu, Jeonju-si, Jeonbuk State 54896, Republic of Korea. Electronic address:
The toxicity of electronic cigarette (EC) aerosol is influenced not only by the type of e-liquid but also by various operational parameters of the device used to vaporize it. In this study, we utilized a flask and heating mantle system, instead of a conventional EC device, to systematically evaluate the effects of EC device operational parameters, including vaporization temperature, airflow rate, and the materials of coils and wicks, on the generated mass of EC aerosol and the production of toxic carbonyl compounds. The results demonstrated that these parameters significantly impact aerosol mass and toxicant composition.
View Article and Find Full Text PDFCurcumin: A Potential Detoxifier Against Chemical and Natural Toxicants.
Phytother Res
January 2025
Chemical and Energy Engineering, Faculty of Engineering, Universiti Teknologi Brunei, Bandar Seri Begawan, Brunei.
The human body gets exposed to a variety of toxins intentionally or unintentionally on a regular basis from sources such as air, water, food, and soil. Certain toxins can be synthetic, while some are biological. The toxins affect the various parts of the body by activating numerous pro-inflammatory markers, like oxidative stresses, that tend to disturb the normal function of the organs ultimately.
View Article and Find Full Text PDFSecondhand Smoke Exposure and Brain Health Indicators in Cuban Preschoolers.
Toxics
January 2025
École de Psychoéducation, Université de Montréal, Montréal, QC H3C 3J7, Canada.
Secondhand smoke affects nearly 40% of children worldwide, leading to serious health and behavioral problems. Being neurotoxic, it poses potential risks for child health and learning. In Cuba, there is limited research on the association of secondhand smoke with children's brain health, especially in vulnerable populations like young children at home.
View Article and Find Full Text PDFE-cigarettes are not associated with post-acute COVID-19 syndrome among US adults.
Sci Rep
January 2025
School of Medicine, Alborz University of Medical Science, Karaj, Iran.
The COVID-19 pandemic has resulted in many survivors experiencing post-acute COVID-19 syndrome (PCS) with symptoms including fatigue, breathlessness, and cognitive complaints. E-cigarette use has already been associated with increased susceptibility to COVID-19 because of its effects on ACE2 receptor expression and inflammation, raising concern that it might worsen the long-term outcomes of COVID-19, including PCS. While traditional smoking is associated with a higher risk of PCS, the role of e-cigarettes remains unclear due to conflicting evidence.
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