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Conceptualizing patient-level adverse effects in implementation trials.
Ann Epidemiol
December 2024
Department of Internal Medicine, University of Botswana, Gaborone, Botswana.
Identifying and monitoring adverse effects (AEs) are integral to ensuring patient safety in clinical trials. Research sponsors and regulatory bodies have put into place a variety of policies and procedures to guide researchers in protecting patient safety during clinical trials. However, it remains unclear how these policies and procedures should be adapted for trials in implementation science.
View Article and Find Full Text PDFAssessment of Emphysema on X-ray Equivalent Dose Photon-Counting Detector CT: Evaluation of Visual Scoring and Automated Quantification Algorithms.
Invest Radiol
October 2024
From the Institute for Diagnostic and Interventional Radiology, University Hospital Zurich, University Zurich, Zurich, Switzerland (B.K., F.E., J.K., T.F., L.J.); Advanced Radiology Center, Department of Diagnostic Imaging and Oncological Radiotherapy, Fondazione Policlinico Universitario "A. Gemelli" IRCCS, Rome, Italy (C.S., A.R.L.); and Section of Radiology, Department of Radiological and Hematological Sciences, Università Cattolica del Sacro Cuore, Rome, Italy (A.R.L.).
Objectives: The aim of this study was to evaluate the feasibility and efficacy of visual scoring, low-attenuation volume (LAV), and deep learning methods for estimating emphysema extent in x-ray dose photon-counting detector computed tomography (PCD-CT), aiming to explore future dose reduction potentials.
Methods: One hundred one prospectively enrolled patients underwent noncontrast low- and chest x-ray dose CT scans in the same study using PCD-CT. Overall image quality, sharpness, and noise, as well as visual emphysema pattern (no, trace, mild, moderate, confluent, and advanced destructive emphysema; as defined by the Fleischner Society), were independently assessed by 2 experienced radiologists for low- and x-ray dose images, followed by an expert consensus read.
Navigating the Institutional Review Board and other institutional entities: An ode to aspiring YPAR scholars.
Am J Community Psychol
December 2024
Institutional Review Board, Boston University, Boston, Massachusetts, USA.
Youth-led participatory action research (YPAR) engages young people as partners in rigorous research inquiry to guide and inform collective action. Scholars interested in YPAR have notable investment in social justice and activist values, which at times come in direct tensions within their doctoral training and/or professional roles within academia. One monumental hurdle in conducting YPAR is obtaining approval from the Institutional Review Board (IRB).
View Article and Find Full Text PDF"I have never felt so alone and vulnerable" - A qualitative study of bereaved people's experiences of end-of-life cancer care during the Covid-19 pandemic.
BMC Palliat Care
December 2024
Marie Curie Research Centre, Division of Population Medicine, School of Medicine, Cardiff University, Cardiff, UK.
Background: COVID-19 drastically affected healthcare services world-wide. In the UK, many cancer services were overwhelmed as oncology staff were reassigned, and cancer diagnoses and treatments were delayed. The impact of these pressures on end-of-life care for patients with advanced cancer and their relatives is not well understood.
View Article and Find Full Text PDFResilient gas dependency-based planning of electricity distribution systems considering energy storage systems.
Risk Anal
December 2024
Department of Electrical Engineering, Shahreza Campus, University of Isfahan, Isfahan, Iran.
This article presents a planning framework to improve the weather-related resilience of natural gas-dependent electricity distribution systems. The problem is formulated as a two-stage stochastic mixed integer linear programing model. In the first stage, the measures for distribution line hardening, gas-fired distributed generation (DG) placement, electrical energy storage resource allocation, and tie-switch placement are determined.
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