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Do not Forget to Measure the Head: Hydrocephalus Can Phenotypically Mimic Developmental Coordination Disorder.
J Child Neurol
January 2025
Department of Pediatric Neurology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
Developmental Coordination Disorder (DCD) is a neurodevelopmental condition presenting with poor motor skill development and impaired coordination at a young age. To diagnose DCD, neurologic conditions explanatory for the phenotype, including structural brain abnormalities like hydrocephalus, must be first ruled out. However, these neurologic conditions may phenotypically mimic DCD, which can hamper their distinction.
View Article and Find Full Text PDFComparison of principal component analysis algorithms for imputation in agrometeorological data in high dimension and reduced sample size.
PLoS One
December 2024
São Paulo State University (Unesp), School of Sciences and Engineering, Tupã, São Paulo, Brasil.
Meteorological data acquired with precision, quality, and reliability are crucial in various agronomy fields, especially in studies related to reference evapotranspiration (ETo). ETo plays a fundamental role in the hydrological cycle, irrigation system planning and management, water demand modeling, water stress monitoring, water balance estimation, as well as in hydrological and environmental studies. However, temporal records often encounter issues such as missing measurements.
View Article and Find Full Text PDFPredicting the toxic side effects of drug interactions using chemical structures and protein sequences.
Sci Rep
December 2024
School of Public Health, Chongqing Medical University, 1 Yixueyuan Road, Yuzhong District, Chongqing, 400016, China.
The study aims to address the critical issue of toxic side effects resulting from drug combinations, which can significantly increase health risks, clinical complications, and lead to drug being withdrawn from the market. A model named TSEDDI (toxic side effects of drug-drug interaction) has been developed to improve the identification of drug pairs that may induce toxicity or adverse reactions. By utilizing drug chemical structures and diverse proteins, we employ a convolutional neural network (CNN) to extract features from molecular images, enzyme proteins, transporter proteins, and target proteins.
View Article and Find Full Text PDFAnticancer Effect of C19-Position Substituted Geldanamycin Derivatives Targeting NRF2-NQO1-activated Esophageal Squamous Cell Carcinoma.
Mol Cell Biol
December 2024
Department of Biochemistry and Molecular Biology, Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan.
In esophageal squamous cell carcinoma, genetic activation of NRF2 increases resistance to chemotherapy and radiotherapy, which results in a significantly worse prognosis for patients. Therefore NRF2-activated cancers create an urgent clinical need to identify new therapeutic options. In this context, we previously identified the geldanamycin family of HSP90 inhibitors, which includes 17DMAG, to be synthetic lethal with NRF2 activity.
View Article and Find Full Text PDFA systematic review of parent-child communication in pediatric asthma.
J Pediatr Psychol
December 2024
Nemours Children's Health, Jacksonville, FL, United States.
Objective: Parent-child communication is integral to pediatric asthma management. This review evaluates parent-child communication among youth with asthma and their caregivers. It aims to characterize the type of communication according to a unifying framework (Murphy, L.
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