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Improving the arthritis component of the SLEDAI-2K.
Rheumatology (Oxford)
December 2024
NIHR Leeds Biomedical Research Centre, Leeds Teaching Hospitals NHS Trust, Leeds, UK.
Objective: To propose a new definition for SLEDAI arthritis informed by imaging.
Methods: We performed a planned secondary analysis of observational data from a multicentre study evaluating SLE patients with inflammatory joint pain (swelling not required) using various clinical instruments, laboratory tests and ultrasound. For SLEDAI arthritis, assessors (blinded to ultrasound) were asked which of the glossary terms for arthritis in any version of the SLEDAI drove their decision to score for arthritis.
Evaluation of the Hand and Wrist via Telephone and Video Visit.
Cureus
February 2023
Departments of Family Medicine, and Orthopedics and Sports Medicine, Mayo Clinic, Jacksonville, USA.
Background: The COVID-19 pandemic has highlighted the utility of telemedicine, with rapid incorporation throughout 2020. Telemedicine is a timely, safe, and effective means of evaluating, triaging, and treating patient conditions, including those of the musculoskeletal system. Hand and wrist complaints are frequently encountered in the primary care setting, and some can have serious consequences if not promptly diagnosed.
View Article and Find Full Text PDFTelehealth examination of the lumbar spine.
Technol Health Care
January 2023
Division of Rheumatology, Penn State Health, Middletown, PA, USA.
Background: Telehealth evaluations of musculoskeletal conditions have increased due to the stay-at-home policies enacted during the COVID-19 pandemic. Back pain is one of the most common complaints in primary care. While telehealth may never supplant in-person evaluation of back pain, it is imperative in a changing world to learn to perform this evaluation via telephone or video.
View Article and Find Full Text PDFBioethics in human embryology: the double-edged sword of embryo research.
Syst Biol Reprod Med
June 2022
Department of Obstetrics and Gynecology, Molecular Medicine & Genetics, C.S. Mott Center for Human Growth and Development, Wayne State University School of Medicine, Detroit, MI, USA.
Article Synopsis
- - There has been a notable rise in assisted reproductive therapies (ARTs), enabling many infertile couples to conceive, but these techniques may also lead to epigenetic risks affecting the health of gametes and embryos, with potential long-term consequences.
- - Research has been conducted to understand the molecular mechanisms behind these ART-induced epigenetic changes using human and animal models, while highlighting the ethical responsibilities of researchers and embryologists regarding the perceived unnaturalness of ART procedures.
- - The discussion includes the moral implications of human embryo research, the ethical use of model systems to study embryogenesis, and the controversial 14-day culture limit for human embryos, suggesting that scientific inquiry should continue as long as ethical boundaries are respected.
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