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Isolated Central Nervous System Involvement after Brentuximab Vedotin Treatment for HIV-Positive ALK-Negative Anaplastic Large Cell Lymphoma.
Case Rep Hematol
February 2024
Diabetes and Hematology Division, National Hospital Organization Kanmon Medical Center, 1-1, Sotouracho, Shimonoseki, Yamaguchi 752-8510, Japan.
Human immunodeficiency virus (HIV)-associated lymphoma poses a high mortality risk despite antiretroviral therapy (ART). Although intermediate- or high-grade B-cell lymphomas are common, anaplastic large-cell lymphomas (ALCLs) are rare and seldom affect the central nervous system (CNS). Herein, we present a case of HIV-associated ALCL with isolated CNS involvement that occurred following the discontinuation of ART that was administered after treatment with brentuximab vedotin (BV)-which does not cross the blood-brain barrier.
View Article and Find Full Text PDFShould CD4 Levels be Monitored in a Patient on Temozolomide?
Eur J Case Rep Intern Med
March 2021
John H Stroger Jr Hospital of Cook County, Chicago, Illinois, USA.
Introduction: Temozolomide is an alkylating agent, indicated in the treatment of refractory anaplastic astrocytoma and newly diagnosed glioblastoma. We describe a case of bacteraemia associated with septic arthritis in the setting of concurrent temozolomide use.
Case: A 67-year-old woman presented with acute onset of bilateral knee pain and swelling.
Secondary glioblastoma metastasis outside the central nervous system in a young HIV-infected patient.
Ther Adv Med Oncol
May 2020
Instituto Estadual do Cérebro Paulo Niemeyer, Rua do Rezende 156, Rio de Janeiro, RJ, 20231-092, Brazil.
Glioblastoma is the most common adult primary brain tumor that occurs in the central nervous system and is characterized by rapid growth and diffuse invasiveness with respect to the adjacent brain parenchyma, which renders surgical resection inefficient. Although it is a highly infiltrative tumor, it is rarely disseminated beyond the central nervous system, wherein extracranial metastasis is a unique but rare manifestation of this kind of tumor. It is very common for acquired immunodeficiency syndrome (AIDS) patients to be infected with the human immunodeficiency virus (HIV), which suggests that a possible association between HIV infection and tumor development exists.
View Article and Find Full Text PDFrearrangement in AIDS-associated ALK-negative anaplastic large cell lymphoma.
BMJ Case Rep
September 2019
Dermatology, Yale University School of Medicine, New Haven, Connecticut, USA.
Patients with AIDS have increased risk of developing lymphomas, such as anaplastic large cell lymphoma (ALCL), which generally carry a poor prognosis. The genetic rearrangement in ALCL confers a favourable prognosis in HIV-negative patients; it is unknown how this interacts clinically with HIV/AIDS. A man aged 53 years presented with subcutaneous nodules on the scalp and axillae, and diffuse lymphadenopathy.
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