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Growth, physiological and molecular response of calcium and salicylic acid primed wheat under lead stress.
Mol Biol Rep
January 2025
Plant Protection and Bimolecular Diagnosis Department, Arid Lands Cultivation Research Institute, City of Scientific Research and Technological Applications, New Borg El-Arab 21934, Alexandria, Egypt.
Background: Heavy metal contamination, particularly from lead (Pb), poses a significant threat to plant agriculture worldwide, adversely affecting growth, physiological functions, and yield. Signalling molecules such as calcium and salicylic acid are known to mitigate various stresses in plants, prompting this study to explore their interaction with Pb stress in wheat.
Methods: A pot experiment was conducted in which wheat grains were primed with either distilled water, 5 mM calcium (Ca), or 0.
Optimizing mRNA translation efficiency through rational 5'UTR and 3'UTR combinatorial design.
Gene
January 2025
State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou 510060, China. Electronic address:
Advances in molecular medicine and biotechnology have demonstrated messenger RNA (mRNA)-based therapies to be a promising therapeutic modality for infectious diseases, genetic disorders, and cancers. However, key challenges persist, including low translation efficiency and short half-life of exogenous mRNA. The untranslated regions (UTRs) influence important parameters like mRNA stability and translation efficiency.
View Article and Find Full Text PDFmiR-143-3p/TET1 Axis Regulates GPC1 Through DNA Methylation and Impairs the Malignant Biological Behaviour of HCC via the Hippo Signalling Pathway.
J Cell Mol Med
January 2025
Department of Hepatobiliary Surgery, The People's Hospital of Tongnan District Chongqing city, Chongqing, China.
Hepatocellular carcinoma (HCC) is a malignant tumour that poses a serious threat to human health and places a heavy burden on individuals and society. However, the role of GPC1 in the malignant progression of HCC is unknown. In this study, we analysed the expression of GPC1 in HCC, and its association with poor patient prognosis.
View Article and Find Full Text PDFRisk factors and prediction model for sub-threshold depression in young and middle-aged breast cancer patients.
Am J Transl Res
December 2024
Psychological Medicine Center, The First Affiliated Hospital of Xinjiang Medical University Urumqi 830000, Xinjiang Uygur Autonomous Region, China.
Objective: To explore the current status of subthreshold depression in young and middle-aged breast cancer patients and its influencing factors, in order to guide early identification and intervention in clinical settings.
Methods: The study included 385 young and middle-aged cancer patients treated at the First Affiliated Hospital of Xinjiang Medical University from June 2023 to June 2024. Standardized scales were used to evaluate sub-threshold depression, psychological resilience, and self-perceived burden.
Posterior epidural migration of thoracic and lumbar disc material: a comprehensive 63-year systematic review with anatomical perspectives.
Neurosurg Rev
January 2025
Department of Neurosurgery, Kermanshah University of Medical Sciences, Kermanshah, Iran.
This study aims to thoroughly investigate the clinical presentation, duration of symptoms, radiological aspects of posterior epidural migration of disc fragments (PEMDF), and assess various treatment options and their impacts on patient functionality. A systematic review was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. We conducted a comprehensive search in PubMed, Web of Science, and Scopus from inception to March 2024.
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