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Anti-ceramide antibody and sphingosine-1-phosphate as potential biomarkers of unresectable non-small cell lung cancer.
Pathol Oncol Res
January 2025
Department of Pulmonology, Semmelweis University, Budapest, Hungary.
Objectives: Spingosine-1-phosphate (S1P) and ceramides are bioactive sphingolipids that influence cancer cell fate. Anti-ceramide antibodies might inhibit the effects of ceramide. The aim of this study was to assess the potential role of circulating S1P and anti-ceramide antibody as biomarkers in non-small cell lung cancer (NSCLC).
View Article and Find Full Text PDFUtilizing machine-learning techniques on MRI radiomics to identify primary tumors in brain metastases.
Front Neurol
January 2025
Department of Radiology, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Objective: To develop a machine learning-based clinical and/or radiomics model for predicting the primary site of brain metastases using multiparametric magnetic resonance imaging (MRI).
Materials And Methods: A total of 202 patients (87 males, 115 females) with 439 brain metastases were retrospectively included, divided into training sets (brain metastases of lung cancer [BMLC] = 194, brain metastases of breast cancer [BMBC] = 108, brain metastases of gastrointestinal tumor [BMGiT] = 48) and test sets (BMLC = 50, BMBC = 27, BMGiT = 12). A total of 3,404 quantitative image features were obtained through semi-automatic segmentation from MRI images (T1WI, T2WI, FLAIR, and T1-CE).
Case report: Electrical impedance tomography-guided ventilator weaning in an obese patient with severe pneumonia.
Front Med (Lausanne)
January 2025
Intensive Care Unit, Zhongshan City People's Hospital, Zhongshan City, China.
Background: Electrical impedance tomography (EIT) evaluates lung function by providing continuous, real-time monitoring of regional lung ventilation distribution to guide the restoration of lung ventilation. Patients with obesity who are dependent on mechanical ventilation often struggle with weaning. This case report highlights the potential of EIT to guide the weaning of ventilator-dependent patients in an obese patient with severe pneumonia.
View Article and Find Full Text PDFCarcinoma of Unknown Primary: Integrating Timely Interventions and Molecular Advancements for Improved Outcomes.
Cureus
December 2024
Hematology and Medical Oncology, University of Kentucky College of Medicine, Lexington, USA.
Carcinoma of unknown primary (CUP) is a diverse group of malignancies characterized by metastatic disease without an identified primary site. It typically presents with a poor prognosis due to widespread metastasis at diagnosis. This report discusses a 58-year-old female patient with advanced CUP and diffuse liver metastasis.
View Article and Find Full Text PDFTingling, Numbness, and Underlying Malignancy: A Case Report of Glioblastoma Multiforme.
Cureus
December 2024
General Medicine, Dartford and Gravesham NHS Trust, Dartford, GBR.
Glioblastoma multiforme (GBM) is a World Health Organisation (WHO) grade IV glioma originating from astrocytes. It is the most common malignant primary tumour of the brain and central nervous system (CNS) and is associated with fast progression and violent local spread, with a median overall survival of approximately 15 months after diagnosis. Due to its late and varied presentation, it is often diagnosed only after it has grown considerably.
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