Immunotherapy of type 1 diabetes. | LitMetric

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Immunotherapy of type 1 diabetes. | LitMetric

Immunotherapy of type 1 diabetes.

Li Li Zuoan Yi Roland Tisch Bo Wang

Arch Immunol Ther Exp (Warsz)

Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7290, USA.

Published: October 2008

Type 1 diabetes (T1D) is an autoimmune disease in which the insulin-producing beta cells are destroyed. Diabetic patients manage their hyperglycemia by daily insulin injections. However, insulin therapy is by no means a cure. Accordingly, a significant effort has been ongoing to develop immunotherapies that effectively prevent and/or treat T1D in the clinic. This review focuses on antigen- and antibody-based immunotherapies and discusses the respective strengths and weaknesses of these approaches.

Download full-text PDF	Source
http://dx.doi.org/10.1007/s00005-008-0025-2	DOI Listing

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