AI Article Synopsis
- Giant cell glioblastoma is a rare form of glioblastoma, accounting for 5% of cases, and is classified separately by the World Health Organization.
- The paper reviews its clinical features, imaging findings, histological and immunohistochemical characteristics, and genetic changes.
- It also discusses treatment options and prognosis, highlighting a case of a patient who lived for 19 months before dying from spinal leptomeningeal metastases.
Article Abstract
Giant cell glioblastoma is an infrequent variety of glioblastoma (5% of the cases). It has deserved a separate category in the World Health Organization classification of grade IV tumors. The clinical, imaging, histological and immunohistochemical characteristics, and the genetic alterations are reviewed. Treatment and prognosis are discussed and updated. The case of a patient that survived 19 months and died of spinal leptomeningeal metastases is illustrated.
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| http://dx.doi.org/10.1016/s1130-1473(08)70221-5 | DOI Listing |
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