AI Article Synopsis
- The study identifies a new serine/threonine kinase, Snrk-1, that regulates angioblast migration and differentiation in embryonic zebrafish.
- Snrk-1 is essential for the migration and maintenance of angioblasts, but not their differentiation; its kinase activity is particularly important.
- The gene is positioned in the signaling pathway related to notch and gridlock in artery-vein development, and its function is conserved in humans, indicating evolutionary similarities.
Article Abstract
In vertebrates, molecular mechanisms dictate angioblasts' migration and subsequent differentiation into arteries and veins. In this study, we used a microarray screen to identify a novel member of the sucrose nonfermenting related kinase (snrk-1) family of serine/threonine kinases expressed specifically in the embryonic zebrafish vasculature and investigated its function in vivo. Using gain- and loss-of-function studies in vivo, we show that Snrk-1 plays an essential role in the migration, maintenance, and differentiation of angioblasts. The kinase function of Snrk-1 is critical for migration and maintenance, but not for the differentiation of angioblasts. In vitro, snrk-1 knockdown endothelial cells show only defects in migration. The snrk-1 gene acts downstream or parallel to notch and upstream of gridlock during artery-vein specification, and the human gene compensates for zebrafish snrk-1 knockdown, suggesting evolutionary conservation of function.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2635085 | PMC |
| http://dx.doi.org/10.1182/blood-2008-06-162156 | DOI Listing |
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