Total syntheses of the natural immunosuppressant myriocin (1) and the equipotent unnatural analogue 2-epi-myriocin (in protected form) have been achieved through a common strategy. The key transformations are the efficient synthesis of a quaternary (E)-vinylglycine by asymmetric deconjugative alkylation of a dehydroamino acid and an unusually highly diastereoselective dihydroxylation of the vinylglycine alkene.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1021/ol801709c | DOI Listing |
Publication Analysis
Top Keywords
total synthesis
4
synthesis immunosuppressants
4
immunosuppressants myriocin
4
myriocin 2-epi-myriocin
4
2-epi-myriocin total
4
total syntheses
4
syntheses natural
4
natural immunosuppressant
4
immunosuppressant myriocin
4
myriocin equipotent
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!