A functional polymorphism of the brain-derived neurotrophic factor, BDNF Val66Met, is associated with risk for major depression alongside impairments in memory and selective attention. This study aims to identify the mediating neural mechanisms in links between BDNF and depression using highly heritable electroencephalographic (EEG) recordings. In 305 healthy subjects, BDNF Val66Met genotypes were compared in terms of trait depression, neural function (EEG during a resting state) and cognitive performance. The mediating effects of the EEG brain imaging endophenotypes were also examined using structural equation (path) modeling. A genotype-endophenotype-phenotype path model showed that Met homozygosity predicted elevated working memory commission errors and altered EEG activity; that is elevated relative theta and delta power coupled with reduced alpha power. In turn, reduced EEG alpha activity mediated the relationship between the Met/Met genotype and trait depression. These findings demonstrate the utility of an integrative endophenotype approach. They suggest that the BDNF Met/Met homozygote has a direct impact on memory systems, but impacts trait depression via the secondary effects of neural changes.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.biopsycho.2008.07.004 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
The Tinnitus Handicap Inventory Total Score: What Really Counts? Experience on a Sample of 1156 Patients.
Audiol Res
January 2025
ENT Division, IRCCS San Raffaele Scientific Institute, 20132 Milano, Italy.
Background: Tinnitus is a frequent symptom, and is present in 10-15% of people who suffer from chronic tinnitus, defined as heard every day for at least 6 months. Among these, 1-2% develop a strong emotive reaction, anxiety, and depression, leading to poor quality of life.
Objectives: to evaluate the comorbidities in tinnitus sufferers.
The Influence of Depression, Anxiety, and Stress on Ageism Among Undergraduates: Mediating Roles of Life Satisfaction, Gratitude, and Prosociality.
Psychol Res Behav Manag
January 2025
Department of General Education, Jiangxi Youth Vocational College, Nanchang, Jiangxi, People's Republic of China.
Background: The rapid growth of the global aging population highlights the need to address ageism and promote social inclusiveness. While considerable research has explored the impact of perceived ageism on older adults' mental health, limited attention has been given to how negative mental health factors-such as depression, anxiety, and stress (DAS)-influence ageist attitudes among younger populations, along with the psychological mechanisms underlying this relationship.
Purpose: This study first investigates the prevalence of ageism among undergraduates and its variation across certain socio-demographic factors at the research site.
A global overview of shared genetic architecture between smoking behaviors and major depressive disorder in European and East Asian ancestry.
J Affect Disord
January 2025
Department of Environmental Genomics, School of Public Health, Nanjing Medical University, Nanjing, China; Department of Genetic Toxicology, The Key Laboratory of Modern Toxicology of Ministry Education, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, China. Electronic address:
Background: The co-occurrence of smoking behaviors and major depressive disorder (MDD) has been widely documented in populations. However, the underlying mechanism of this association remains unclear.
Methods: Genome-wide association studies of smoking behaviors and MDD, combined with multi-omics datasets, were usedto characterise genetic correlations, identify shared loci and genes, and explore underlying biological mechanisms.
Short communication: The importance of random effects in detecting purging of inbreeding depression: A model comparison in Pannon White rabbits.
Animal
December 2024
Institute of Animal Sciences, Hungarian University of Agriculture and Life Sciences Institution, 40, Guba S. str., H-7400 Kaposvár, Hungary.
Inbreeding depression (ID) is a well-documented phenomenon associated with reduced fitness and possible extinction. However, ID can be mitigated or even eliminated through the interplay of inbreeding and selection, a process known as purging. The aim of this study was to compare the predictive power of two commonly used approaches in models with and without random dam effects to detect purging (full and reduced models).
View Article and Find Full Text PDFRisk factors associated with pain and pain relief in patients with chronic pancreatitis.
Postgrad Med J
January 2025
Department of Gastroenterology, Affiliated Hospital of Qingdao University, No. 16 Jiangsu Road, Shinan District, Qingdao 266075, China.
Background: Abdominal pain is one of the most prominent symptoms in patients with chronic pancreatitis (CP) and can manifest intermittently or persistently. The mechanism of pain is not yet clear, and no effective treatment is currently available. This study aimed to explore the risk factors for pain in patients with CP, which may provide new insights for developing effective pain control modalities.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!