Objective: To investigate penetration characteristics of artemether and the effect of different permeation enhancer on transdermal permeation of artemether through rat skin.
Method: The permeation experiments were performed using rat skin on modified Franz diffusion cells in vitro. The concentrations of artemether in receptor compartment at specified time points were determined by HPLC.
Result: The permeating ratio through human skin of artemether solution was Js (2.78 +/- 0.78) microg x cm(-2) x h(-1), the quantity of drug penetrated through and accumulated in the skin by the end of the experiment were (69.07 +/- 3.01) microg x cm(-2), (58.93 +/- 3.56) microg x cm(-2) respectively. Four different permeation enhancers can improve the transdermal permeation of artemether.
Conclusion: Artemether have the potential to be developed to new transdermal preparation.
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Zhongguo Zhong Yao Za Zhi
December 2024
College of Pharmaceutical Sciences, Guizhou University of Traditional Chinese Medicine Guiyang 550025, China National Engineering Technology Research Center for Miao Medicine Guiyang 550025, China Guizhou Engineering Technology Research Center for Processing and Preparation of Traditional Chinese Medicine and Ethnic Medicine Guiyang 550025, China.
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