Aphasia has traditionally been viewed as a loss or impairment of language. However, evidence is presented suggesting that language mechanisms are fundamentally preserved and that aphasic language behaviors are instead due to impairments of cognitive processes supporting their construction. These processes may be understood as a linguistically specialized attentional system that is vulnerable to competition from other processing domains. We present two models of attention that focus on competition for central processing and discuss findings from dual-task studies of normal and aphasic performance. First, competing language and nonlanguage tasks appear to share limited-capacity, parallel processing resources. Second, aphasic individuals demonstrate slowed central processing that could be due to a reduction in processing capacity or ability to allocate that capacity. Third, the attention models discussed bear a coherent relationship to current models of language processing. Clinical implications of a cognitive processing account of aphasia are also considered.
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http://dx.doi.org/10.1055/s-0028-1082882 | DOI Listing |
J Cheminform
January 2025
Department of Intelligent Electronics and Computer Engineering, Chonnam National University, Gwangju, Republic of Korea.
The human ether-a-go-go-related gene (hERG) channel plays a critical role in the electrical activity of the heart, and its blockers can cause serious cardiotoxic effects. Thus, screening for hERG channel blockers is a crucial step in the drug development process. Many in silico models have been developed to predict hERG blockers, which can efficiently save time and resources.
View Article and Find Full Text PDFItal J Pediatr
January 2025
High Institute of Public Health, Alexandria University, Alexandria, Egypt.
Background: Attention-Deficit Hyperactivity Disorder (ADHD) is a complex disease that negatively impacts the social and academic/occupational activities of children and is more common in boys than in girls.
Methods: This case-control study aimed to assess the association between some environmental risk factors and ADHD among children in Alexandria, Egypt. It was carried out at the outpatient clinics of El Shatby Pediatric University Hospital in Alexandria, Egypt, with 252 children (126 cases and 126 controls).
Orphanet J Rare Dis
January 2025
Laboratory of Neurogenetics and Molecular Medicine, Center for Genomic Sciences in Medicine, Institut de Recerca Sant Joan de Déu, Únicas SJD Center, Hospital Sant Joan de Déu, Barcelona, Spain.
Background: Rare diseases (RDs) are a heterogeneous group of complex and low-prevalence conditions in which the time to establish a definitive diagnosis is often too long. In addition, for most RDs, few to no treatments are available and it is often difficult to find a specialized care team.
Objectives: The project "acERca las enfermedades raras" (in English: "bringing RDs closer") is an initiative primary designed to generate a consensus by a multidisciplinary group of experts to detect the strengths and weaknesses in the public healthcare system concerning the comprehensive care of persons living with a RD (PLWRD) in the region of Catalonia, Spain, where a Network of Clinical Expert Units (Xarxa d'Unitats de Expertesa Clínica or XUEC) was created and is being implemented since 2015.
Curr Nutr Rep
January 2025
School of Medical, Indigenous and Health Sciences, Faculty of Science, Medicine and Health, University of Wollongong NSW, Wollongong, 2522, Australia.
Purpose Of The Review: Clinical trials suggest that dietary anthocyanins may enhance cognitive function. This systematic literature review and meta-analysis aimed to identify the effect of anthocyanin on cognition and mood in adults.
Recent Findings: Using a random-effects model, Hedge's g scores were calculated to estimate the effect size.
Brain Imaging Behav
January 2025
Department of Radiology, Zhongnan Hospital of Wuhan University, Wuchang, Wuhan, Hubei, 430071, China.
This study investigates post-stroke cognitive impairment (PSCI) by utilizing spectral dynamic causal modeling (spDCM) to examine changes in effective connectivity (EC) within the default mode, executive control, dorsal attention, and salience networks. Forty-one PSCI patients and 41 demographically matched healthy controls underwent 3D-T1WI and resting-state functional magnetic resonance imaging on a 3.0T MRI.
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