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Novel Insights in Perioperative Neuroprotection in Neonatal Congenital Heart Disease.
Acta Paediatr
January 2025
Neonatal Research Unit, Health Research Institute La Fe, University and Polytechnics Hospital La Fe, Valencia, Spain.
Congenital heart disease (CHD) includes defects of intrauterine cardiac development that result in alterations to the morphology and/or physiology of the heart, usually expressed early in fetal or postnatal life. This group represents one of the most common congenital anomalies of all living newborns worldwide. Neurodevelopmental deficits are a reality in patients with CHDs and may contribute to significant sequela and long-term morbidity beginning in infancy and extending into adulthood.
View Article and Find Full Text PDFAn Argument for More High-Quality Research Focused on Mental Health in the Post-Secondary Context.
Early Interv Psychiatry
February 2025
Bloomberg Faculty of Nursing, University of Toronto, Toronto, Ontario, Canada.
We argue that while a substantial proportion of emerging adults are in post-secondary education, there is relatively little consideration of this context within research and policy around youth mental health. The unique challenges young adults face in post-secondary education overlay underlying risk factors experienced by emerging adults. While post-secondary education facilitates social mobility, it also introduces stressors such as academic demands, financial insecurity and social isolation.
View Article and Find Full Text PDFInsect size responses to climate change vary across elevations according to seasonal timing.
PLoS Biol
January 2025
Department of Biology, University of Washington, Seattle, Washington, United States of America.
Body size declines are a common response to warming via both plasticity and evolution, but variable size responses have been observed for terrestrial ectotherms. We investigate how temperature-dependent development and growth rates in ectothermic organisms induce variation in size responses. Leveraging long-term data for six montane grasshopper species spanning 1,768-3 901 m, we detect size shifts since ~1960 that depend on elevation and species' seasonal timing.
View Article and Find Full Text PDFManagement of presymptomatic juvenile patients with late-onset Pompe disease (LOPD).
Neuromuscul Disord
January 2025
ERN-NMD Center for Neuromuscular Disorders of Messina - Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy. Electronic address:
Late-onset Pompe disease (LOPD) includes patients from 1 year of age to adulthood. The vast heterogeneity in clinical manifestations and disease progression is not fully explained; however, a short disease duration and a young age seem to be good predictors of a better response to treatment. For this purpose, we investigated and followed up a cohort of 13 juvenile patients with LOPD from the clinical and therapeutic point of view, mainly pointing out the transition from presymptomatic to symptomatic status.
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