Memory-guided saccades (MGSs) with 3 s memorization delay were recorded in healthy subjects using four different paradigms: two "regular" MGS paradigms with the peripheral target lit for 0.2 s (MGS2) and for 1.8 s (MGS18); a multiple memory-guided saccade (MMGS) paradigm with the target lit for 1.8 s and the instruction to perform a visually guided saccade (VGS) towards it before the MGS; a trained memory-guided saccades (TMGSs) paradigm where the same target was presented so that the subjects should made 10 VGSs before the MGS. The longer target presentation interval (MGS18 paradigm) did not improve the accuracy of MGS. The execution of the VGSs improved the accuracy of the corrective saccades made after the first MGS to drive the eyes closer to the target, and this improvement was independent from the number of the VGSs (there was no difference between the MMGS and the TMGS paradigms). The VGSs provide a template that improves the capability of the corrective saccades to compensate for the residual position error at the end of the first saccade.
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http://dx.doi.org/10.1016/S0079-6123(08)00662-6 | DOI Listing |
Unlabelled: Delay period activity in the dorso-lateral prefrontal cortex (dlPFC) has been linked to the maintenance and control of sensory information in working memory. The stability of working memory related signals found in such delay period activity is believed to support robust memory-guided behavior during sensory perturbations, such as distractors. Here, we directly probed dlPFC's delay period activity with a diverse set of activity perturbations, and measured their consequences on neural activity and behavior.
View Article and Find Full Text PDFJ Clin Med
September 2024
Department of Neurology, Osijek University Hospital Center, 31000 Osijek, Croatia.
Cervical dystonia (CD) is a condition characterized by involuntary activity of cervical muscles, which is often accompanied by various non-motor symptoms. Recent studies indicate impaired saccadic eye movements in CD. Local administration of botulinum toxin type A (BoNT/A), which causes temporary paralysis of the injected muscle, is the first-line treatment of focal dystonia, including CD.
View Article and Find Full Text PDFAtten Percept Psychophys
October 2024
Department of Optometry, Manipal College of Health Professions, Manipal Academy of Higher Education, Manipal, Karnataka, India.
Glaucoma is a progressive optic neuropathic disorder that significantly impacts the activities of daily life (ADLs) of individuals. Emerging studies indicate degenerative changes in cortical and subcortical regions in individuals with glaucoma, which are associated with cognitive processes and oculomotor control. Cognitive processes involving top-down processes such as attention, planning, task management and execution, are crucial for meeting the demands of everyday tasks, and are affected in glaucoma.
View Article and Find Full Text PDFBackground: White noise stimulation has demonstrated efficacy in enhancing working memory in children with ADHD. However, its impact on other executive functions commonly affected by ADHD, such as inhibitory control, remains largely unexplored. This research aims to explore the effects of two types of white noise stimulation on oculomotor inhibitory control in children with ADHD.
View Article and Find Full Text PDFBiomedicines
July 2024
Department of Neuroscience, Iuliu Hațieganu University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania.
Background: Ischemic stroke (IS) often leads to cognitive and motor impairments. This study aimed to investigate whether Memory-Guided Saccade Tasks (MGSTs) could be used to assess cognitive function in stroke patients.
Methods: A secondary data analysis was conducted on 62 individuals with supratentorial IS.
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