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A reproducible framework for monitoring the impact of randomized clinical trials on clinical practice using large-scale real-world data: application to gynaecological surgical trials using the French national healthcare database.
EClinicalMedicine
February 2025
Department of Breast and Gynaecological Surgery, Institut Curie, Paris, France.
Background: Randomized clinical trials (RCTs) are fundamental to evidence-based medicine, but their real-world impact on clinical practice often remains unmonitored. Leveraging large-scale real-world data can enable systematic monitoring of RCT effects. We aimed to develop a reproducible framework using real-world data to assess how major RCTs influence medical practice, using two pivotal surgical RCTs in gynaecologic oncology as an example-the LACC (Laparoscopic Approach to Cervical Cancer) and LION (Lymphadenectomy in Ovarian Neoplasms) trials.
View Article and Find Full Text PDFAfter-hours, Severity, and Distance are Associated with Non-VHA Emergency Department Use for Older Veterans: Insights from a Regional Health Information Exchange.
J Geriatr Emerg Med
December 2024
Geriatric Research Education and Clinic Center, James J. Peters VA Medical Center, 130 W Kingsbridge Rd, Bronx, NY 10468 & Department of Medicine, Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Pl, New York, NY 10029.
Background: Older adults treated in emergency departments (EDs) are at higher risk for adverse outcomes. Using multiple facilities can worsen this issue through service duplication and poor care transitions. Veterans with dual insurance coverage can access both Veterans Health Administration (VHA) and non-VHA EDs.
View Article and Find Full Text PDFBackground And Aim: Managing benign biliary stricture endoscopically is complicated and challenging. This study aimed to evaluate the safety and efficacy of a 6-month placement of a fully covered self-expanding metallic stent for refractory benign biliary stricture.
Methods: Twenty-two patients with refractory benign biliary stricture (13 with chronic pancreatitis and 9 without) were recruited from five higher tertiary care centers.
Access to public health care and associated factors in rural areas: a cross-sectional community-based study in Bopa district, Southern Benin.
Pan Afr Med J
October 2024
Institut de Recherche Clinique du Bénin (IRCB), Abomey-Calavi, Benin.
Introduction: despite the considerable progress made to date, access to health care in public health facilities remains a challenging public health problem in Benin. This study aimed to assess trends in access to care over five years and to identify factors associated with low access to care.
Methods: a cross-sectional community-based study was conducted in the Bopa district, a rural area of southern Benin between January and February 2020.
Barriers and facilitators to telemedicine contraception among patients that speak Spanish: a qualitative study.
AJOG Glob Rep
February 2025
Division of Complex Family Planning, Department of Obstetrics Gynecology and Reproductive Sciences, University of California San Diego, La Jolla, CA (Meurice, Kully, Averbach and Mody).
Background: Telemedicine contraception services have increased since the COVID-19 pandemic. There may be unique equity implications and language barriers for patients who speak Spanish.
Objective: To identify the barriers and facilitators of telemedicine for contraception care among patients who speak Spanish using a community-based participatory research approach.
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