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Age-dependent modulation of bone metabolism in zebrafish scales as new model of male osteoporosis in lower vertebrates.
Geroscience
April 2021
IRCCS Istituto Ortopedico Galeazzi, Milan, Italy.
After middle age, in human bone, the resorption usually exceeds formation resulting in bone loss and increased risk of fractures in the aged population. Only few in vivo models in higher vertebrates are available for pathogenic and therapeutic studies about bone aging. Among these, male Danio rerio (zebrafish) can be successfully used as low vertebrate model to study degenerative alterations that affect the skeleton during aging, reducing the role of sex hormones.
View Article and Find Full Text PDFEfficacy of additional treatment with azathioprine in a patient with prednisolone-dependent gastric sarcoidosis.
World J Gastroenterol
December 2016
Masaki Murata, Yoshihiro Yokota, Osamu Inatomi, Shigeki Bamba, Akira Andoh, Department of Gastroenterology, Shiga University of Medical Science Hospital, Otsu 520-2192, Japan.
Gastric sarcoidosis with noncaseating granuloma is rare. Although corticosteroid produces a dramatic clinical response, it is unknown whether azathioprine show efficacy in prednisolone-dependent cases. Here, we report a case of gastric sarcoidosis in a 25-year-old man with severe epigastlargia.
View Article and Find Full Text PDF[Neuro-neutrophilic Disease and Dementia].
Brain Nerve
April 2016
Departments of Neurology and Clinical Research Center, National Hospital Organization, Miyagi Hospital.
Article Synopsis
- - Neuro-neutrophilic diseases, like neuro-Behçet and neuro-Sweet disease, cause inflammation in the nervous system due to abnormal neutrophil movement triggered by bacterial infections and cytokine imbalances.
- - Certain human leukocyte antigens (HLAs), specifically HLA-B51 and HLA-B54/Cw1, are found at higher rates in patients with neurological issues related to these diseases, indicating they are significant risk factors.
- - Treatment options include corticosteroids like prednisolone, immunosuppressants, and dapsone for chronic cases, with dementia being a notable symptom, particularly in chronic neuro-Behçet disease, which is recognized as a treatable form of dementia.
Prothrombotic state in patients with severe and prednisolone-dependent asthma.
J Allergy Clin Immunol
June 2016
Department of Respiratory Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
Background: Epidemiologic studies have shown that asthmatic patients, in particular those with severe disease, have increased risk of pulmonary embolism. It is unknown whether these patients have a prothrombotic state under stable conditions.
Objective: We sought to compare coagulation and fibrinolysis parameters between healthy subjects and patients with mild, severe, and prednisolone-dependent asthma under stable conditions and to investigate whether hemostatic markers correlate with airway inflammation.
[Neuro-Behçet disease and neuro-Sweet disease].
Rinsho Shinkeigaku
April 2014
Department of Neurology, Miyagi National Hospital.
Behçet disease and Sweet disease are multisystem inflammatory disorders involving mucocutaneous tissue as well as nervous system (neuro-Behçet disease and neuro-Sweet disease). Pathological findings in the encephalitis are chiefly perivascular cuffing of small venules by neutrophils, T lymphocytes, and macrphages. Destruction of the brain substrates is mild in neuro-Sweet disease compared with that of neuro-Behçet disease, especially that of chronic progressive subtype.
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