A new series of bis-aminomethylnaphthalenes were synthesized in satisfactory overall yield, through a simple synthetic strategy using reductive amination. The DNA binding properties of these compounds have been examined and compared to those of reference drugs using an UV spectroscopy method. The compounds were evaluated for their in vitro anticancer activity and some of them were studied in vivo. Compound 15 exhibited remarkable antitumor activity and represents a novel template for anticancer chemotherapy and can serve as a new lead compound.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.bmc.2008.07.069 | DOI Listing |
Publication Analysis
Top Keywords
antitumor activity
8
design synthesis
4
synthesis antitumor
4
activity bis-aminomethylnaphthalenes
4
bis-aminomethylnaphthalenes series
4
series bis-aminomethylnaphthalenes
4
bis-aminomethylnaphthalenes synthesized
4
synthesized satisfactory
4
satisfactory yield
4
yield simple
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!