AI Article Synopsis
- The derivatives of 4-(hetero)aryl-4-oxobut-2-enoic acid are valuable in creating biologically active compounds.
- A new, efficient synthesis protocol was developed using microwave assistance and an ytterbium triflate catalyst.
- This method enables quick production of these acids with isolated yields ranging from 52-75%, starting from various (hetero)aromatic ketones and glyoxylic acid monohydrate.
Article Abstract
The derivatives of 4-(hetero)aryl-4-oxobut-2-enoic acid are useful as building blocks in the synthesis of biologically active compounds. An efficient general protocol for the synthesis of these building blocks was developed. This method combines microwave assistance and ytterbium triflate catalyst and allows the fast preparation of the target acids starting from different (hetero)aromatic ketones and glyoxylic acid monohydrate giving pure products in 52-75% isolated yields.
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| http://dx.doi.org/10.1021/cc800103f | DOI Listing |
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