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Science
January 2025
H. Holden Thorp is Editor-in-Chief of the Science journals.
Floyd Bloom, who died on 8 January, was a towering figure in both neuroscience and the scientific community as a whole. As Editor-in-Chief of from 1995 to 2000, he presided over a transformative period in which the journal embraced the digital age, expanding its reach and impact while advocating for open access and the sharing of data. His groundbreaking contributions to neuropharmacology and the understanding of neurotransmitters were only part of his legacy.
View Article and Find Full Text PDFMikhail 'Misha' Blagosklonny's enduring legacy in geroscience: the hyperfunction theory and the therapeutic potential of rapamycin.
Aging (Albany NY)
January 2025
Geneva College of Longevity Science, Geneva 1204, Switzerland.
The untimely passing of Dr. Mikhail "Misha" Blagosklonny has left a lasting void in geroscience and oncology. This review examines his profound contributions, focusing on his pioneering the Hyperfunction Theory and his advocacy for rapamycin, an mTOR inhibitor, as a therapeutic agent for lifespan extension.
View Article and Find Full Text PDFLaser-Induced Olfactory Bulbectomy in Adult Zebrafish as a Novel Putative Model for Affective Syndrome: A Research Tribute to Brian Leonard.
Eur J Neurosci
January 2025
Scientific Center for Genetics and Life Sciences, Sirius University of Science and Technology, Federal Territory Sirius, Sirius, Russia.
Inducing multiple neurobehavioural and neurochemical deficits, olfactory bulbectomy (OBX) has been developed as a rodent model of depression with potential for antidepressant drug screening. However, the generality of this model in other vertebrate taxa remains poorly understood. A small freshwater teleost fish, the zebrafish (Danio rerio), is rapidly becoming a common model species in neuroscience research.
View Article and Find Full Text PDFHow should we bend the curve of biodiversity loss to build a just and sustainable future?
Philos Trans R Soc Lond B Biol Sci
January 2025
Georgina Mace Centre for the Living Planet, Silwood Park, Ascot SL5 7PY, UK.
Current rates of habitat and biodiversity loss, and the threat they pose to ecological and economic productivity, would be considered a global emergency even if they were not occurring during a period of rapid anthropogenic climate change. Diversity at all levels of biological organization, both within and among species, and across genomes and communities, is critical for the resilience of the world's ecosystems in the face of such change. However, it remains an urgent scientific challenge to understand how biodiversity underpins these ecological outputs, how patterns of biodiversity are being affected by current threats, and how and where such biodiversity contributes most directly to human economies, well-being and social justice.
View Article and Find Full Text PDFRadiation-induced cardiac disease: Modern techniques to reduce cardiac toxicity.
Pract Radiat Oncol
January 2025
The Legacy Heritage Oncology Center & Dr Larry Norton Institute, Soroka University Medical Center, Ben Gurion University of the Negev, Faculty of Medicine, Be'er Sheva, Israel.
Purpose: Continuous advancements in cancer management have resulted in increased long-term survival rates amongst cancer survivors and in turn have exposed the full extent of radiotherapy-associated morbidities. Radiation-induced coronary heart disease (RICHD) is one of the leading causes of morbidity and mortality in cancer survivors, particularly in those having undergone mediastinal radiation. While mediastinal radiation has been shown to substantially reduce both recurrence and mortality rates in multiple thoracic malignancies, the risk for the development of RICHD is of significant concern.
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